{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T09:04:27Z","timestamp":1750064667236},"reference-count":20,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T00:00:00Z","timestamp":1613692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004791","name":"Shenzhen Graduate School, Peking University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004791","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We evaluated the safety and efficacy of the novel dual\u2010therapy sirolimus\u2010eluting and endothelial progenitor cell (EPC) capture COMBO stent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>(Very) late stent thrombosis (ST) and neo\u2010atherosclerosis limit the performance of drug\u2010eluting stents. The capture of EPCs accelerates stent re\u2010endothelialization, thereby potentially decreasing the risk of restenosis and ST.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 440 patients with de novo lesions in native coronary arteries were randomized (1:1) to either receive the COMBO stent (n = 220) or Nano polymer\u2010free sirolimus\u2010eluting stent (n = 220). The primary endpoint was the 9\u2010month angiographic in\u2010segment late lumen loss (LLL). Secondary endpoints included target lesion failure (TLF), a patient\u2010oriented composite endpoint (PoCE), and ST.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 9 months, the COMBO in\u2010segment LLL (0.29\u2009\u00b1\u20090.46\u2009mm) was non\u2010inferior to that of the Nano comparator stent (0.31\u2009\u00b1\u20090.44\u2009mm;<jats:italic>p<\/jats:italic><jats:sub>non\u2010inferiority<\/jats:sub>\u2009&lt;\u2009.0001). Clinical outcomes were also similar between the COMBO and Nano stents, with TLF rates of 9.3% and 7.9% (<jats:italic>p<\/jats:italic>= .61) at 12\u2009months, and 9.4% and 8.0% (<jats:italic>p<\/jats:italic>= .62) at 24\u2009months, respectively. The PoCE rate was 14.8% and 10.6% (<jats:italic>p<\/jats:italic>= .19) at 12\u2009months, and 16.0% and 11.3% (<jats:italic>p<\/jats:italic>= .16) at 24\u2009months, respectively. Ischemia\u2010driven target lesion revascularization rates were 6.0% and 3.7% (<jats:italic>p<\/jats:italic>= .26) at 12\u2009months, and 6.2% and 3.8% (<jats:italic>p<\/jats:italic>=\u2009.26) at 24\u2009months, respectively. No case of ST occurred in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The RECOVERY trial has shown the COMBO stent was effective, meeting the primary non\u2010inferiority angiographic endpoint, and safe, with an overall low rate of clinical events in both stent groups, including no ST for up to 2\u2009years.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29553","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T23:06:50Z","timestamp":1613862410000},"page":"966-975","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>Nine\u2010month<\/scp>angiographic and<scp>2\u2010year<\/scp>clinical outcomes of the<scp>RECOVERY<\/scp>trial: A randomized study of the biodegradable polymer<scp>sirolimus\u2010eluting COMBO dual\u2010therapy<\/scp>stent versus a<scp>polymer\u2010free sirolimus\u2010eluting<\/scp>stent in Chinese patients"],"prefix":"10.1002","volume":"97","author":[{"given":"Ling","family":"Tao","sequence":"first","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Air Force Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanquan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The People Hospital of Liaoning Province Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyong","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First Affiliated Hospital of Air Force Medical University Xi'an China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhua","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, TEDA International Cardiovascular Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tianjin Chest Hospital Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Daqing Oilfields General Hospital Daqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Medical Research and Biometrics Center, National Center for Cardiovascular Diseases Beijing 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