{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:13:31Z","timestamp":1790745211520,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T00:00:00Z","timestamp":1613692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81700440"],"award-info":[{"award-number":["81700440"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to assess the safety, blood pressure changes, and biochemical responses of superselective adrenal artery embolization (SAAE) in hypertensive patients with idiopathic hyperaldosteronism (IHA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>SAAE is a minimally invasive procedure that has been used to successfully treat aldosterone\u2010producing adenoma. However, its effect for patients with IHA is unevaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 41 hypertensive patients who were diagnosed with IHA and underwent SAAE at the Fuwai Hospital between December 2010 and June 2016 were prospectively enrolled. The blood pressure, antihypertensive medications, plasma aldosterone and potassium levels, and adverse events were assessed. The primary endpoint was the change in home blood pressure at 12\u2009months, compared with baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SAAE was technically successful in 39 patients. Postoperatively, home and 24\u2010hr mean blood pressures were reduced by 14\/9 and 10\/7\u2009mmHg at 1 month, respectively, and by 13\/7 and 11\/7\u2009mmHg at 12\u2009months, respectively. The number of antihypertensive agents used reduced by 1.0 and 1.1 at 1 month and 12\u2009months, respectively (all <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Compared with baseline (524.0 pmol\/L), the standing plasma aldosterone reduced to 293.4 pmol\/L at 12\u2009months (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Serum potassium increased from 3.0 to 4.1\u2009mmol\/L while the rate of potassium supplement and mineralocorticoid receptor antagonist use reduced from 87.1 and 89.7%, respectively, to 28.2 and 17.9%, respectively, at 12\u2009months (all <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). There were no serious complications in the perioperative and 12\u2010month follow\u2010up periods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SAAE was effective and feasible for IHA treatment, without serious complications, therefore, maybe a potential treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29554","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T23:11:14Z","timestamp":1613862674000},"page":"976-981","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Superselective adrenal arterial embolization for idiopathic hyperaldosteronism: 12\u2010month results from a proof\u2010of\u2010principle trial"],"prefix":"10.1002","volume":"97","author":[{"given":"Hui","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubao","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jining","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5391-2474","authenticated-orcid":false,"given":"Yu","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1165-7302","authenticated-orcid":false,"given":"Bo","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runlin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0187-8379","authenticated-orcid":false,"given":"Xiongjing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Fuwai Hospital National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing 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