{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:49:43Z","timestamp":1773013783591,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Based on coronary angiography and mean aortic pressure, a specially designed computational flow dynamics (CFD) method is proposed to determine contrast fractional flow reserve (cFFR) without using invasive pressure wire. This substudy assessed diagnostic performance of coronary angiography\u2010derived cFFR in catheterization laboratory, based on a previous multicenter trial for online assessment of coronary angiography\u2010derived FFR (caFFR).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Patients with diagnosis of stable angina pectoris or unstable angina pectoris were enrolled in six centers. Wire\u2010based FFR was measured in coronary arteries with 30\u201390% diameter stenosis. Offline angiography\u2010derived cFFR was computed in blinded fashion against the wire\u2010based FFR and caFFR at an independent core laboratory.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>A total of 330 patients were enrolled to fulfill inclusion\/exclusion criteria from June 26 to December 18, 2018. Offline angiography\u2010derived cFFR and wire\u2010based FFR results were compared in 328 interrogated vessels. The statistical analysis showed the highest diagnostic accuracy of 89.0 and 86.6% for angiography\u2010derived cFFR with a cutoff value of 0.94 and 0.93 against the wire\u2010based FFR with a cutoff value of 0.80 and 0.75, respectively. The corresponding sensitivity and specificity were 92.2 and 87.3% for the cutoff value of 0.94 and 80.0 and 88.4% for the cutoff value of 0.93, which are similar to those against the caFFR. The receiver\u2010operating curve has area under the curve of 0.951 and 0.972 for the wire\u2010based FFR with the cutoff value of 0.80 and 0.75, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Coronary angiography\u2010derived cFFR showed higher accuracy, sensitivity, and specificity against wired\u2010based FFR and caFFR. Hence, angiography\u2010derived cFFR could enhance the hemodynamic assessment of coronary lesions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29558","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T17:44:33Z","timestamp":1613670273000},"page":"763-771","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Coronary <scp>angiography\u2010derived<\/scp> contrast fractional flow reserve"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1281-1073","authenticated-orcid":false,"given":"Yanjun","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Cardiology Peking University First Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology Peking University First Hospital  Beijing 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