{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:36:10Z","timestamp":1786977370663,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>A retrospective case series of a percutaneous approach to debulk tricuspid valve endocarditis (TVE) using an 8 French mechanical aspiration system in patients with a history of intravenous drug use (IVDU) was reported. IVDU associated TVE is increasing in the United States and is associated with high mortality despite early surgical debridement. Patients with advanced disease, shock, and respiratory failure may not be candidates for surgical debridement or replacement. These patients have recurrent events despite medical therapy<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>About 25 patients with IVDU associated TVE with persistent bacteremia confirmed by repeat blood cultures after 72\u2009hr of sensitivity directed antibiotics and presence of pulmonary emboli confirmed by computed tomographic (CT) scan, who had undergone percutaneous aspiration were included. Patients were all deemed high risk for surgical debridement by a CT surgeon and evaluated by an infectious disease consultant. Procedures were performed under moderate sedation with intracardiac echo and a steerable guide with a CAT8 Penumbra aspiration catheter.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There were no intraprocedural deaths or complications. About 36% had septic shock on presentation. Survival of index hospitalization was 88%. Repeat blood cultures showed no growth on all surviving patients. Readmission rate was 4% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01) at 1\u00a0month. About 40% (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02) patients with septic shock survived at 1\u00a0month compared with 100% survival (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a020) in those without shock. Presence of septic shock was associated with reduced survival at 1\u00a0month (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Percutaneous mechanical aspiration with an 8 Fr system is a feasible, minimally invasive alternative to surgical debulking. Mortality remains high in those presenting with septic shock. Further studies are needed to evaluate long\u2010term outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.29584","type":"journal-article","created":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T05:49:28Z","timestamp":1614577768000},"page":"1290-1295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinical outcomes of percutaneous debulking of tricuspid valve endocarditis in intravenous drug users"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6360-5459","authenticated-orcid":false,"given":"Yasir N.","family":"Akhtar","sequence":"first","affiliation":[{"name":"Tennova Healthcare, Turkey Creek Medical Center  Knoxville Tennessee US"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Walker","sequence":"additional","affiliation":[{"name":"Tennova Healthcare, Turkey Creek Medical Center  Knoxville Tennessee 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