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on the use of mechanical circulatory support (MCS) devices in the treatment of AMI\u2010CS and difficulties which may be encountered in conducting such trials in the United States.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Well powered randomized control trials are difficult to conduct in a critically ill patient population due to physician preferences, perceived lack of equipoise and challenges obtaining informed consent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>With growth in utilization of MCS devices in patients with AMI\u2010CS, efforts to perform well\u2010powered, randomized control trials must be 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