{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T09:29:08Z","timestamp":1770456548279,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T00:00:00Z","timestamp":1615075200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Right ventricular (RV) dysfunction and tricuspid regurgitation (TR) are associated with adverse outcomes in severe aortic stenosis (AS) patients. Our aim was to evaluate the association between \u2265moderate TR and RV dysfunction on long\u2010term mortality following transcatheter aortic valve replacement (TAVR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of the Israeli multicenter TAVR registry among 4,344 consecutive patients, with all\u2010cause mortality as the main outcome measure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Echocardiographic assessment of TR grade and RV dysfunction was available for 3,733 and 1,850 patients, of whom \u2265moderate TR and RV dysfunction was noted for 478(13%) and 78(4%), respectively. The mean follow\u2010up time was 2.9\u00a0\u00b1\u20092.3\u2009years. In univariate models, \u2265Moderate TR and \u2265moderate RV dysfunction were associated with increased long\u2010term mortality (HR 1.45, 95% CI 1.24\u20131.69, <jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001 and HR 1.73, 95% CI 1.21\u20132.47, <jats:italic>p<\/jats:italic>\u00a0=\u20090.003, respectively). These finding did not remained significant after adjusting to echocardiographic parameters. A subset of patients with no improvement in RV function had the highest long\u2010term mortality risk (HR 3.3, 95% CI 1.95\u20135.7, <jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>When adjusted to multiple echocardiographic characteristics baseline \u2265Moderate TR and \u2265moderate RV dysfunction were not associated with long\u2010term mortality following TAVR. Persistent RV dysfunction following TAVR was associated with the highest risk for mortality.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29639","type":"journal-article","created":{"date-parts":[[2021,3,8]],"date-time":"2021-03-08T06:52:13Z","timestamp":1615186333000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prognostic implication of right ventricular dysfunction and tricuspid regurgitation following transcatheter aortic valve replacement"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3863-4493","authenticated-orcid":false,"given":"Yoav","family":"Granot","sequence":"first","affiliation":[{"name":"Department of Cardiology, Tel Aviv Medical Center Sackler School of Medicine, Tel Aviv University  Tel Aviv 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