{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:40:52Z","timestamp":1747147252996,"version":"3.40.5"},"reference-count":5,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Key Points<\/jats:title><jats:p><jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Significant paravalvular leak (PVL) among patients undergoing transcatheter aortic valve replacement (TAVR) portends a poor prognosis and is often associated with increased mortality.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>TAVR with the latest generation balloon\u2010expandable valve platform, Edwards SAPIEN 3 Ultra, is associated with lower incidence of PVL (including lower rates of mild PVL and zero incidence of moderate and severe PVL) compared to its predecessor, the SAPIEN 3 valve platform.<\/jats:p><\/jats:list-item>\n<jats:list-item><jats:p>The similar safety profile, comparable deliverability, and lower PVL observed with the Edwards SAPIEN 3 Ultra system will likely lead to its increased adoption in clinical practice. Future studies are needed to examine its long\u2010term clinical outcomes and further decipher the procedural and patient factors associated with PVL.<\/jats:p><\/jats:list-item>\n<\/jats:list><\/jats:p>","DOI":"10.1002\/ccd.29666","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T01:08:14Z","timestamp":1618448894000},"page":"903-904","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Paravalvular leak after TAVR: <i>remarkable improvement but not the time to shift focus<\/i>"],"prefix":"10.1002","volume":"97","author":[{"given":"Dhruv","family":"Mahtta","sequence":"first","affiliation":[{"name":"Section of Cardiology, Department of Medicine Baylor College of Medicine  Houston Texas USA"},{"name":"Section of Cardiology, Department of Medicine Michael E. 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