{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T23:53:30Z","timestamp":1773446010801,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T00:00:00Z","timestamp":1620172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This multicenter, prospective clinical study investigates whether the microelectromechanical\u2010systems\u2010(MEMS)\u2010sensor pressure microcatheter (MEMS\u2010PMC) is comparable to a conventional pressure wire in fractional flow reserve (FFR) measurement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>As a conventional tool for FFR measurement, pressure wires (PWs) still have some limitations such as suboptimal handling characteristics and unable to maintain the wire position during pullback assessment. Recently, a MEMS\u2010PMC compatible with any 0.014\u2033 guidewire is developed. Compared with the existing optical\u2010sensor PMC, this MEMS\u2010PMC has smaller profiles at both the lesion crossing and sensor packaging areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred and forty\u2010two patients with visually 30\u201370% coronary stenosis were enrolled at four centers. FFR was measured first with the MEMS\u2010PMC, and then with the PW. The primary endpoint was the Bland\u2013Altman mean bias between the MEMS\u2010PMC and PW FFR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From the 224\u2010patient per\u2010protocol data, quantitative coronary angiography showed 17.9% and 55.9% vessels had diameter\u2009&lt;\u20092.5\u2009mm and stenosis &gt;50%, respectively. The two systems' mean bias was \u22120.01 with [\u22120.08, 0.06] 95% limits\u2010of\u2010agreement. Using PW FFR\u22640.80 as cutoff, the MEMS\u2010PMC per\u2010vessel diagnostic accuracy was 93.4% [95% confidence interval: 89.4\u201396.3%]. The MEMS\u2010PMC's success rate was similar to that of PW (97.5 vs. 96.3%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.43) with no serious adverse event, and its clinically\u2010significant (&gt;0.03) drift rate was 43% less (9.5 vs. 16.7%, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study showed the MEMS\u2010PMC is safe to use and has a minimal bias equal to the resolution of current FFR systems. Given the MEMS\u2010PMC's high measurement accuracy and rapid\u2010exchange nature, it may become an attractive new tool facilitating routine coronary physiology assessment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29678","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T09:43:58Z","timestamp":1620294238000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Multicenter clinical evaluation of a piezoresistive\u2010MEMS\u2010sensor rapid\u2010exchange pressure microcatheter system for fractional flow reserve measurement"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5287-5269","authenticated-orcid":false,"given":"Chenguang","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiology Zhongshan Hospital, Fudan University  Shanghai 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