{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T05:16:05Z","timestamp":1781846165094,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T00:00:00Z","timestamp":1617667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>A large\u2010diameter, intravascular, self\u2010expanding stent system capable of continued expansion during somatic and vascular growth was modeled with finite element analysis (FEA), manufactured and tested in an animal model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Children can quickly outgrow intravascular stents. If a stent could expand after implantation in arteries this would be ideal for use in pediatric patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Computer\u2010aided design and FEA were used to design and manufacture large\u2010diameter, self\u2010expanding nitinol stents with both high and low chronic outward force (COF). Four distinct stents with similar designs but with variable lengths and strut thicknesses were manufactured. Fourteen of these stents were implanted in the abdominal aortas or iliac arteries of four juvenile swine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All animals survived without complication to their designated time points of harvest (90 or 180\u2010days), and all stents expanded to greater diameters than the adjacent non\u2010stented artery. Luminal diameter growth was 34\u201349% and 20\u201323% for stented and non\u2010stented segments, respectively. Histologic examination revealed variable degrees of the internal elastic lamina and\/or medial disruption with a mean injury score ranging from 0.70\u2009\u00b1\u20090.56 to 1.23\u2009\u00b1\u20090.21 and low COF stents implanted in smaller arteries having a larger injury score. Inflammatory responses and stenosis formation were minimal and ranged from 0.50\u2009\u00b1\u20090.71 to 3.00\u2009\u00b1\u20090.00 and 5.52\u2009\u00b1\u20091.05% to 14.68\u2009\u00b1\u20099.12%, respectively. The stent's COF did not correlate with vessel expansion or vascular injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Self\u2010expanding stents can mirror and even exceed somatic growth. Although longer\u2010term testing is needed, it may be possible to custom tailor self\u2010expanding stents to expand after arterial implantation in pediatric patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29679","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T05:43:51Z","timestamp":1617774231000},"page":"139-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Can a <scp>self\u2010expanding<\/scp> pediatric stent expand with an artery? 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