{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:40:55Z","timestamp":1747147255386,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T00:00:00Z","timestamp":1617580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We investigated whether the dual antiplatelet therapy (DAPT) score (DS) predicts clinical outcome in an East\u2010Asian population that received exclusively second generation drug\u2010eluting stent (DES).<\/jats:p><\/jats:sec><jats:sec><jats:title>Backgrounds<\/jats:title><jats:p>It is uncertain whether the DS could adequately risk stratify patients exclusively receiving second generation DES.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From the Grand\u2010DES registry, we evaluated patients who were treated with DAPT for at least 12\u2009months and were event\u2010free at 12\u2009months after DES implantation. Patients were classified into two categories: high DS (\u22672) (<jats:italic>n<\/jats:italic>\u00a0=\u00a03,157); and low DS (&lt;2) (<jats:italic>n<\/jats:italic>\u00a0=\u00a05,226). The primary ischemic outcome was a composite of stent thrombosis and all myocardial infarction (MI), and the primary bleeding outcome was TIMI major or minor bleeding. A propensity score (PS)\u2010matched analysis was done to correct for baseline differences between extended DAPT group and the conventional group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 8,383 subjects, the primary ischemic outcome occurred in 48 patients (0.6%) and the primary bleeding outcome in 49 patients (0.6%). High DS was associated with a higher incidence of ischemic events (ischemic outcome: 0.8% vs. 0.4%, for high vs. low DS, Log\u2010rank <jats:italic>p<\/jats:italic>\u00a0=\u00a0.039), but not with any differences in bleeding events (Log\u2010rank <jats:italic>p<\/jats:italic>\u00a0=\u00a0.734). In the PS\u2010matched analysis, extended group was associated with lower risk of composite endpoint of MI, stent thrombosis, or cardiac death in only the high DS group (1.8% vs. 3.7%, Log\u2010rank <jats:italic>p<\/jats:italic>\u00a0=\u00a0.004; hazard ratio 0.45, 95% confidence interval 0.27\u20130.76; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.003 after adjustment).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The DS was an adequate risk stratifier for future ischemic events in East Asians receiving exclusively second generation DES.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29682","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T07:55:41Z","timestamp":1617609341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The validation of the dual antiplatelet therapy score in East Asians receiving percutaneous coronary intervention with exclusively second generation <scp>drug\u2010eluting<\/scp> stents"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4079-8219","authenticated-orcid":false,"given":"Minkwan","family":"Kim","sequence":"first","affiliation":[{"name":"Cardiovascular Center, Department of Internal Medicine Seoul National University Hospital  Seoul South Korea"},{"name":"Division of Cardiology, Department of Internal Medicine Yongin Severance Hospital, Yonsei University College of Medicine  Yongin South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2432-4432","authenticated-orcid":false,"given":"Kyung Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Department of Internal Medicine Seoul National University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hak Seung","family":"Lee","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Department of Internal Medicine Seoul National University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0102-2810","authenticated-orcid":false,"given":"You\u2010Jeong","family":"Ki","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Department of Internal Medicine Seoul National University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeehoon","family":"Kang","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Department of Internal Medicine Seoul National University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chee\u2010Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Department of Internal Medicine Seoul National University Hospital  Seoul South Korea"},{"name":"Division of Cardiology, Department of Internal Medicine Sejong General Hospital  Bucheon South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0016-0747","authenticated-orcid":false,"given":"Jung\u2010Kyu","family":"Han","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Department of Internal Medicine Seoul National University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han\u2010Mo","family":"Yang","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Department of Internal Medicine Seoul National University Hospital  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun\u2010Jae","family":"Kang","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Department of Internal Medicine Seoul National University Hospital  Seoul South 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