{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:44:30Z","timestamp":1761864270411,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Coronary sinus (CS) reducer implantation is associated with symptomatic relief of patients with refractory angina. However, 15% to 30% of the patients do not respond to this treatment. Aim if this study was to evaluate the effect of CS size in the effectiveness of the device.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prior to device implantation and at 4\u2010month resting ventricular function was assessed by stress cardiac magnetic resonance. Ischemia was assessed by the myocardial perfusion reserve index (MPRI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen patients (66\u2009\u00b1\u200910\u2009years) underwent successful CS Reducer implantation, with improvements in angina class and exercise tolerance. Patients with a smaller CS size (&lt;5.8\u2009mm) presented a significantly higher percentage increase in MPRI (63\u2009\u00b1\u200951 vs 9\u00a0\u00b1\u200930%, <jats:italic>P<\/jats:italic>\u00a0=\u2009.03) and a higher reduction in left ventricle end\u2010diastolic volumes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Greater benefits, in terms of ischemia improvement, after CS Reducer implantation were seen in patients with smaller CS sizes, suggesting a potential mechanism underlying the observed rates of reducer non\u2010responsiveness.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29699","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:28:28Z","timestamp":1618446508000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Coronary sinus size and ischemia improvement after reducer implantation; \u201cone size to fit them all?\u201d"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5286-7843","authenticated-orcid":false,"given":"Georgios","family":"Tzanis","sequence":"first","affiliation":[{"name":"Unit of Cardiovascular Interventions IRCCS San Raffaele Scientific Institute  Milan Italy"},{"name":"Interventional Cardiology Department Henry Dunant Hospital Center  Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4455-2865","authenticated-orcid":false,"given":"Arif A","family":"Khokhar","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit GVM Care &amp; Research Maria Cecilia Hospital  Cotignola Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0135-5551","authenticated-orcid":false,"given":"Francesco","family":"Ponticelli","sequence":"additional","affiliation":[{"name":"Unit of Cardiovascular Interventions IRCCS San Raffaele Scientific Institute  Milan Italy"},{"name":"Interventional Cardiology Unit GVM Care &amp; Research Maria Cecilia Hospital  Cotignola Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8011-6844","authenticated-orcid":false,"given":"Guglielmo","family":"Gallone","sequence":"additional","affiliation":[{"name":"Unit of Cardiovascular Interventions IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Palmisano","sequence":"additional","affiliation":[{"name":"Department of Radiology and Experimental Imaging Centre IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Esposito","sequence":"additional","affiliation":[{"name":"Department of Radiology and Experimental Imaging Centre IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2130-1964","authenticated-orcid":false,"given":"Alessandro","family":"Beneduce","sequence":"additional","affiliation":[{"name":"Unit of Cardiovascular Interventions IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Guarracini","sequence":"additional","affiliation":[{"name":"Department of Cardiology Pierangeli Clinic  Pescara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Colombo","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit GVM Care &amp; Research Maria Cecilia Hospital  Cotignola Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0517-1410","authenticated-orcid":false,"given":"Francesco","family":"Giannini","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Unit GVM Care &amp; Research Maria Cecilia Hospital  Cotignola Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402556"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2018.06.116"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2020.09.045"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2020.03.042"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-20-00873"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCIMAGING.119.009148"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-14-65"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-10-35"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28206"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28417"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-17-00626"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28580"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.29699","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.29699","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.29699","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T12:13:53Z","timestamp":1692706433000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.29699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,14]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/ccd.29699"],"URL":"https:\/\/doi.org\/10.1002\/ccd.29699","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"type":"print","value":"1522-1946"},{"type":"electronic","value":"1522-726X"}],"subject":[],"published":{"date-parts":[[2021,4,14]]},"assertion":[{"value":"2020-04-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}