{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:44:13Z","timestamp":1761745453677,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to explore angiographic patterns and in\u2010hospital outcomes of patients with concomitant coronavirus disease\u201019 (COVID\u201019) and myocardial infarction (MI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with COVID\u201019 may experience MI during the course of the viral infection. However, this association is currently poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a multicenter prospective study of consecutive patients with concomitant COVID\u201019 and MI who underwent coronary angiography. Quantitative and qualitative coronary angiography were analyzed by two observers in an independent core lab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 152 patients were included, of whom 142 (93.4%) had COVID\u201019 diagnosis confirmation. The median time between symptom onset and hospital admission was 5 (1\u201310) days. A total of 83 (54.6%) patients presented with ST\u2010elevation MI. The median angiographic Syntax score was 16 (9.0\u201325.3) and 69.0% had multi\u2010vessel disease. At least one complex lesion was found in 73.0% of patients, 51.3% had a thrombus containing lesion, and 57.9% had myocardial blush grades 0\/1. The overall in\u2010hospital mortality was 23.7%. ST\u2010segment elevation MI presentation and baseline myocardial blush grades 0 or 1 were independently associated with a higher risk of death (HR 2.75, 95%CI 1.30\u20135.80 and HR 3.73, 95%CI 1.61\u20138.61, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients who have a MI in the context of ongoing COVID\u201019 mostly present complex coronary morphologies, implying a background of prior atherosclerotic disease superimposed on a thrombotic milieu. The in\u2010hospital prognosis is poor with a markedly high mortality, prompting further investigation to better clarify this newly described condition.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29709","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T20:45:32Z","timestamp":1619556332000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Patients with <scp>COVID<\/scp>\u201019 who experience a myocardial infarction have complex coronary morphology and high in\u2010hospital mortality: Primary results of a nationwide angiographic study"],"prefix":"10.1002","volume":"98","author":[{"given":"Alexandre","family":"Abizaid","sequence":"first","affiliation":[{"name":"Heart Institute, InCor University of Sao Paulo Medical School  Sao Paulo Brazil"},{"name":"Department of Cardiology Hospital S\u00edrio Liban\u00eas  Sao Paulo Brazil"},{"name":"Hospital do Cora\u00e7\u00e3o (HCor)  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1734-6924","authenticated-orcid":false,"given":"Carlos M.","family":"Campos","sequence":"additional","affiliation":[{"name":"Heart Institute, InCor University of Sao Paulo Medical School  Sao Paulo Brazil"},{"name":"Department of Cardiology Instituto Prevent Senior  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0626-2250","authenticated-orcid":false,"given":"Patr\u00edcia O.","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Heart Institute, InCor University of Sao Paulo Medical School  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Jos\u00e9 de Ribamar","family":"Costa","sequence":"additional","affiliation":[{"name":"Hospital do Cora\u00e7\u00e3o (HCor)  S\u00e3o Paulo Brazil"},{"name":"Department of Cardiology Dante Pazzanese Institute of Cardiology  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Breno A. A.","family":"Falc\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital de Messejana  Fortaleza Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8212-1732","authenticated-orcid":false,"given":"Fernanda","family":"Mangione","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Benefic\u00eancia Portuguesa  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano","family":"Caixeta","sequence":"additional","affiliation":[{"name":"Escola Paulista de Medicina Universidade Federal de Sao Paulo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro A.","family":"Lemos","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Israelita Albert Einstein  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Fabio S.","family":"de Brito","sequence":"additional","affiliation":[{"name":"Heart Institute, InCor University of Sao Paulo Medical School  Sao Paulo Brazil"},{"name":"Department of Cardiology Hospital S\u00edrio Liban\u00eas  Sao Paulo Brazil"},{"name":"Department of Cardiology Hospital S\u00e3o Camilo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital S\u00e3o Camilo  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4762-0579","authenticated-orcid":false,"given":"Cristiano Guedes","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Ana Nery  Salvador Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro","family":"Cortes","sequence":"additional","affiliation":[{"name":"Department of Cardiology Instituto Nacional de Cardiologia  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrique B.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Cardiology Hospital Samaritano Paulista  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis R.","family":"de Souza","sequence":"additional","affiliation":[{"name":"Heart Institute, InCor University of Sao Paulo Medical School  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natassja","family":"Huemer","sequence":"additional","affiliation":[{"name":"Heart Institute, InCor University of Sao Paulo Medical School  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata M.","family":"do Val","sequence":"additional","affiliation":[{"name":"Heart Institute, InCor University of Sao Paulo Medical School  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Caramelli","sequence":"additional","affiliation":[{"name":"Heart Institute, InCor University of Sao Paulo Medical School  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Calderaro","sequence":"additional","affiliation":[{"name":"Heart Institute, InCor University of Sao Paulo Medical School  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe G.","family":"Lima","sequence":"additional","affiliation":[{"name":"Heart Institute, InCor University of Sao Paulo Medical School  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludhmila A.","family":"Hajjar","sequence":"additional","affiliation":[{"name":"Heart Institute, InCor University of Sao Paulo Medical School  Sao Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5546-262X","authenticated-orcid":false,"given":"Roxana","family":"Mehran","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. 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