{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T03:27:47Z","timestamp":1781753267763,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Using a large nationally representative database, we aimed to examine risk factors for acute kidney injury (AKI) and its association with outcomes in patients undergoing percutaneous left atrial appendage closure (LAAC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous small\u2010scale studies have reported poor outcomes with AKI following percutaneous LAAC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We queried the Nationwide Readmission Database to identify LAAC procedures performed from 2016 to 2017. Multivariable logistic and linear regression models were used to identify risk factors for AKI and determine the association between AKI and clinical outcomes. The primary outcome of interest was in\u2010hospital mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 20,703 patients who underwent LAAC during the study period, 1,097 (5.3%) had a diagnosis of AKI. Chronic kidney disease, non\u2010elective admission, coagulopathy, weight loss, prior coronary artery disease, heart failure, diabetes mellitus, and anemia were independently associated with an increased risk of AKI after LACC. In patients undergoing LAAC, AKI was associated with an increased risk of in\u2010hospital mortality (adjusted odds ratio [aOR], 16.01; 95% CI, 8.48\u201330.21), stroke\/transient ischemic attack (aOR, 2.50; 95% CI, 1.69\u20133.70), systemic embolization (aOR, 3.78; 95% CI, 1.64\u20138.70), bleeding\/transfusion (aOR, 1.96; 95% CI, 1.50\u20132.56), vascular complications (aOR, 3.53; 95% CI, 1.94\u20136.42), pericardial tamponade requiring intervention (aOR, 6.83; 95% CI, 4.37\u201310.66), index length of stay (adjusted parameter estimate, 7.46; 95% CI, 7.02\u20137.92), and 180\u2010day all\u2010cause readmissions (aOR, 1.43; 95% CI, 1.09\u20131.88).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>AKI in the setting of LAAC is uncommon but is associated with poor clinical outcomes. Further studies are needed to determine if a similar association exists for long\u2010term outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29711","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T03:49:08Z","timestamp":1618544948000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of acute kidney injury with outcomes in patients undergoing percutaneous left atrial appendage closure"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8202-9576","authenticated-orcid":false,"given":"Salik","family":"Nazir","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine University of Toledo Medical Center  Toledo Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keerat Rai","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Division of Cardiology Reading Hospital\u2010Tower Health  Reading Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Ariss","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Toledo Medical Center  Toledo Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Hassanein","sequence":"additional","affiliation":[{"name":"Section of Nephrology and Hypertension Cleveland Clinic  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Schurmann","sequence":"additional","affiliation":[{"name":"Section of Cardiology Baylor College of Medicine  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srikanth","family":"Koneru","sequence":"additional","affiliation":[{"name":"Section of Cardiology Baylor College of Medicine  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Afshar","sequence":"additional","affiliation":[{"name":"Section of Cardiology Baylor College of Medicine  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irakli","family":"Giorgberidze","sequence":"additional","affiliation":[{"name":"Section of Cardiology Baylor College of Medicine  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9719-3854","authenticated-orcid":false,"given":"George V.","family":"Moukarbel","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of Toledo Medical Center  Toledo Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8754-358X","authenticated-orcid":false,"given":"Hani","family":"Jneid","sequence":"additional","affiliation":[{"name":"Section of Cardiology Baylor College of Medicine  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.06.016"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2010.09.009"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.09.582"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.07.044"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61343-X"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.04.029"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.15192"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.10.021"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.12.040"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-019-01524-9"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.03.022"},{"key":"e_1_2_8_13_1","unstructured":"NRD Database Documentation.https:\/\/www.hcup-us.ahrq.gov\/db\/nation\/nrd\/nrddbdocumentation.jsp. 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