{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:19:14Z","timestamp":1789154354718,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the outcomes following transcatheter edge\u2010to\u2010edge mitral valve repair (TMVr) in patients with chronic kidney disease (CKD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Percutaneous TMVr is beneficial in high surgical risk patients with severe mitral regurgitation (MR). However, those with CKD are not well studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Utilizing the International Classification of Disease (ninth and tenth revision, clinical modification codes) and the Nationwide Inpatient Sample database, we identified 9,228 patients who underwent TMVr during 2010\u20132016, including those with no or mild CKD (group 1, <jats:italic>n<\/jats:italic>\u00a0=\u00a06,654 [72.11%]), moderate or severe CKD (group 2, <jats:italic>n<\/jats:italic>\u00a0=\u00a02,125 [23.03%]) and end\u2010stage renal disease (ESRD) on dialysis (group 3, <jats:italic>n<\/jats:italic>\u00a0=\u00a0449 [4.86%]). In\u2010hospital clinical outcomes, length of stay and cost were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In\u2010hospital mortality increased numerically as CKD severity increased, but not statistically different between groups (1.8, 3.3, and 4.5% respectively in group 1, 2, and 3, <jats:italic>p<\/jats:italic>\u00a0=\u2009.07). Moderate to severe CKD (group 2) was an independent predictor of acute renal failure requiring hemodialysis (ARFD) (OR: 3.51, CI: 2.33\u20135.28, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001), the composite outcome of death, ARFD or stroke [OR: 3.15, 95% CI: 2.10\u20134.76, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001] and extended length of stay [OR: 1.73, 95% CI: 1.24\u20132.42), <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001] while ESRD (group 3) was an independent predictor of higher hospital cost [OR: 1.66, 95% CI: 1.01\u20132.74), <jats:italic>p<\/jats:italic>\u00a0=\u00a0.04] as compared with no or mild CKD (group 1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High surgical risk patients with severe MR commonly have associated comorbidities including CKD. TMVr outcomes appear to worsen with worsening CKD and therefore careful clinical case selection and further studies evaluating TMVr outcomes in CKD patients is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29712","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T04:47:54Z","timestamp":1618548474000},"page":"1177-1184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["In\u2010hospital outcomes after transcatheter <scp>edge\u2010to\u2010edge<\/scp> mitral valve repair in patients with chronic kidney disease: An analysis from the 2010\u20132016 National inpatient sample"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0495-4085","authenticated-orcid":false,"given":"Hemang B.","family":"Panchal","sequence":"first","affiliation":[{"name":"Florida Heart Center PA, Port St Lucie  Stuart Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg W.","family":"Stone","sequence":"additional","affiliation":[{"name":"Zena and Michael A. Wiener Cardiovascular Institute Icahn School of Medicine at Mount Sinai and The Cardiovascular Research Foundation  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshul","family":"Saxena","sequence":"additional","affiliation":[{"name":"Biostatistics and Predictive Analytics, Baptist Health South Florida  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoran","family":"Bursac","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Florida International University  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emir","family":"Veledar","sequence":"additional","affiliation":[{"name":"Biostatistics and Predictive Analytics, Baptist Health South Florida  Miami Florida USA"},{"name":"Department of Biostatistics Florida International University  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Nagabandi","sequence":"additional","affiliation":[{"name":"Pikeville Medical Center  Pikeville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles J.","family":"Davidson","sequence":"additional","affiliation":[{"name":"Department of Cardiology Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin B.","family":"Leon","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center and The Cardiovascular Research Foundation  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8413-9664","authenticated-orcid":false,"given":"Nirat","family":"Beohar","sequence":"additional","affiliation":[{"name":"Columbia University Division of Cardiology at Mount Sinai Medical Center  Miami Beach Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009355"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.03.077"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.07.065"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2014.05.014"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806640"},{"key":"e_1_2_8_7_1","unstructured":"Healthcare Cost and Utilization Project (HCUP). 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