{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T15:01:16Z","timestamp":1789830076342,"version":"4.0.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T00:00:00Z","timestamp":1621814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Aim of this study is to evaluate short term safety and efficacy of Impella in high risk percutaneous coronary intervention (HR\u2010PCI) population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>While several studies demonstrated the clinical significance of Impella in HR\u2010PCI, few data exist about its impact on short term outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All studies reporting short term outcomes of PCI with any Impella device were included. The primary endpoint was either in\u2010hospital or 30\u2010day mortality, while vascular complications, post\u2010procedural stroke, post\u2010procedural dialysis and bleeding complications were assessed as secondary outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine studies with 7448 patients were included. Median age was 69.5\u2009years old (67\u201373), with a mean ejection fraction of 29.7% (20%\u201339%) and a Syntax score of 30.2 (25. 5\u201333, interquartile [IQR]). Impella 2.5 was the most commonly used axial flow pump used to support these PCIs (88.7%). In\u2010hospital death was observed in 5.09% of patients (95% confidence interval [CI] 3.69\u20136.49, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u200978%), while vascular complications in 2.53% of patients (1.07\u20134.00, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u200989%) and post\u2010procedural stroke in 2.77% of patients (0.50\u20136.05, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u200998%). Major bleeding occurred in 5.98% of patients (3.66\u20138.31, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u200990%) and post\u2010procedural dialysis in 4.44% of patients (1.50\u20137.37, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u200993% all CI 93%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Use of Impella in high risk PCI appears to have an acceptable rate of complication, especially regarding vascular complications and major bleedings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29757","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T13:44:43Z","timestamp":1621863883000},"page":"27-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Short term outcomes of Impella circulatory support for high\u2010risk percutaneous coronary intervention a systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3877-9323","authenticated-orcid":false,"given":"Edoardo","family":"Elia","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medical Science University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Iannaccone","sequence":"additional","affiliation":[{"name":"Division of Cardiology Ospedale San Giovanni Bosco  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6646-9317","authenticated-orcid":false,"given":"Fabrizio","family":"D'Ascenzo","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medical Science University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8011-6844","authenticated-orcid":false,"given":"Guglielmo","family":"Gallone","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medical Science University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Colombo","sequence":"additional","affiliation":[{"name":"Division of Cardiology Ospedale San Giovanni Bosco  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1407-6087","authenticated-orcid":false,"given":"Stefano","family":"Albani","sequence":"additional","affiliation":[{"name":"Division of Cardiology Ospedale San Giovanni Bosco  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Attisani","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery AOU \"Citt\u00e0 della 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Ferrari","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medical Science University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy394"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx437"},{"issue":"23","key":"e_1_2_8_4_1","article-title":"2011 ACCF\/AHA\/SCAI guideline for percutaneous coronary intervention: a report of the American College of Cardiology Foundation\/American Heart Association task force on practice guidelines and the Society for Cardiovascular Angiography and Interventions","volume":"124","author":"Levine 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