{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:21:58Z","timestamp":1790360518076,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T00:00:00Z","timestamp":1622073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sarcopenia is a prevalent condition in elderly patients and has been associated with adverse outcomes following transcatheter aortic valve replacement (TAVR). The present study aimed to determine the predictive value of serum creatinine\u2010cystatin C ratio, that is, \u201cSarcopenia Index\u201d (SI) as a surrogate marker of sarcopenia, and investigate its association with clinical outcomes after TAVR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective observational study of patients undergoing TAVR between January, 2016 and December, 2018 at Hospital Italiano de Buenos Aires, Argentina. Patients were excluded if &lt;65\u2010years old, presented previous surgical aortic valve replacement, severe chronic kidney disease, or hemodialysis requirement. The SI was obtained at baseline before TAVR. All\u2010cause mortality and\/or readmissions for congestive heart failure (CHF) were defined as the primary endpoint.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total 100 patients met inclusion criteria for the purpose of the study. Sarcopenia Index was significantly correlated with Timed Up and Go (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.272,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.010) and Gait Speed (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.278,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.005). During follow\u2010up, 5\/100 patients died within 30\u2009days and a total of 10\/100 patients died at 1\u2010year follow\u2010up. Moreover, survival curves were significantly worse (Log\u2010rank test\u00a0=\u00a0\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.02) and CHF readmissions were more prevalent in the lowest SI tertile (Log\u2010rank test\u00a0=\u00a0\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.01). In multivariate Cox regression analysis, we identified low SI (cutoff \u226466) as an independent predictor of long\u2010term adverse outcomes (HR\u00a0=\u00a04.01, 95% CI\u00a0=\u00a01.31\u201312.27,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.015) at 1\u2010year follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sarcopenia Index, surrogate for the degree of skeletal muscle mass (SMM), could be used as a predictor of adverse outcomes in patients undergoing TAVR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.29799","type":"journal-article","created":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T09:06:48Z","timestamp":1622106408000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Sarcopenia index as a predictor of clinical outcomes in older patients undergoing transcatheter aortic valve replacement"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1261-5785","authenticated-orcid":false,"given":"Francisco Jos\u00e9","family":"Romeo","sequence":"first","affiliation":[{"name":"Department of Interventional Cardiology Hospital Italiano de Buenos Aires  Buenos Aires Argentina"},{"name":"Department of Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2128-8280","authenticated-orcid":false,"given":"Juan Guido","family":"Chiabrando","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Hospital Italiano de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6823-4001","authenticated-orcid":false,"given":"Ignacio Miguel","family":"Seropian","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Hospital Italiano de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Valle","family":"Raleigh","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Hospital Italiano de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horacio Medina","family":"de Chazal","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Hospital Italiano de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian Maximiliano","family":"Garmendia","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Hospital Italiano de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximiliano","family":"Smietniansky","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Geriatrics Hospital Italiano de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariela","family":"Cal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Geriatrics Hospital Italiano de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Romina","family":"Agatiello","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Hospital Italiano de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Horacio","family":"Berrocal","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology Hospital Italiano de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2017.09.008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-017-3999-2"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2019.05.060"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e328333c1c1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-19-00110"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12603-020-1448-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afq034"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1462"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2020.08.014"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9103121"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/56.3.M146"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1991.tb01616.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"e_1_2_8_15_1","first-page":"1","article-title":"Echocardiographic assessment of valve stenosis: EAE\/ASE recommendations for clinical practice","volume":"1","author":"Baumgartner H","year":"2009","journal-title":"J Am Soc Echocardiogr"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-145-4-200608150-00004"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2012.09.002"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.02870707"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2004.09.025"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000073"},{"issue":"1","key":"e_1_2_8_21_1","article-title":"Evaluating muscle mass by using markers of kidney function: development of the sarcopenia index","volume":"45","author":"Kashani KB","year":"2016","journal-title":"Crit Care Med"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/ncn3.11"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13182"},{"issue":"1","key":"e_1_2_8_24_1","article-title":"The serum creatinine to serum cystatin C ratio is a reliable surrogate marker of sarcopenia in patients with Cushing's syndrome in remission","volume":"3","author":"Martel L","year":"2019","journal-title":"Journal of the Endocrine Society"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2018.02.025"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jpen.1492"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-58304-z"},{"issue":"3","key":"e_1_2_8_28_1","first-page":"527","article-title":"Malnutrition and chronic inflammation as risk factors for sarcopenia in elderly patients with hip fracture","volume":"27","author":"Yoo J","year":"2018","journal-title":"Asia Pac J Clin Nutr"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jjcc.2018.11.013"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.19-395"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2018.04.005"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2020.03.021"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12928-020-00725-8"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2018.03.007"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.04.043"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00255"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/309570"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.020279"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.29799","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.29799","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.29799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T11:20:05Z","timestamp":1693135205000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.29799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,27]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,11,15]]}},"alternative-id":["10.1002\/ccd.29799"],"URL":"https:\/\/doi.org\/10.1002\/ccd.29799","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,27]]},"assertion":[{"value":"2021-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}