{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T03:05:28Z","timestamp":1773025528016,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T00:00:00Z","timestamp":1623888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to determine the safety and efficacy of the Allegra transcatheter heart valve (THV) for the treatment of severe aortic valve stenosis in a large patient population treated under real\u2010world conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The Allegra is a novel self\u2010expanding THV with supra\u2010annular bovine leaflets. The valve is available in three different sizes (23, 27, and 31\u2009mm), all are delivered through an 18F sheath.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients undergoing TAVR with the Allegra THV were enrolled in a multicenter\u2010registry. Data were collected throughout initial hospital\u2010stay and at 30\u2010day follow\u2010up. Clinical endpoints were defined according to the updated definitions of the Valve\u2010Academic\u2010Research\u2010Consortium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This registry included 255 patients (mean age 83\u2009\u00b1\u20096\u2009years, 48% women) from four European centers. Median European System for Cardiac Operative Risk Evaluation II score (EuroSCORE II) was 3.3% (IQR 1.9\u20135.8%). Acute device success was 95.7%. The remaining 11 patients had either moderate paravalvular regurgitation immediately after the procedure (7 patients) or the device could not be optimal positioned requiring implantation of a second THV (4 patients). Major vascular complications and major\/life\u2010threatening bleedings occurred in 10 (3.9%) and 12 (4.7%) patients, respectively. At 30\u2009day follow\u2010up, mean effective orifice area was 2.2\u2009\u00b1\u20090.5\u2009cm<jats:sup>2<\/jats:sup>, mean gradient was 6.9\u2009\u00b1\u20093.8\u2009mmHg, 7 (3.3%) patients had more than mild paravalvular leakage, 3 patients (1.2%) had died, 6 patients (2.4%) had a stroke and 30 (12.8%) patients had required implantation of a new permanent pacemaker.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Transfemoral implantation of the Allegra THV resulted in favorable clinical and echocardiographic outcomes during hospitalization and short\u2010term follow up.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29833","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T10:48:45Z","timestamp":1623926925000},"page":"1204-1209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Allegra transcatheter heart valve: Short term results from a multicenter registry"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4494-0128","authenticated-orcid":false,"given":"Mathias","family":"Wolfrum","sequence":"first","affiliation":[{"name":"Heart Center Lucerne Luzerner Kantonsspital  Lucerne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5794-5676","authenticated-orcid":false,"given":"Federico","family":"Moccetti","sequence":"additional","affiliation":[{"name":"Heart Center Lucerne Luzerner Kantonsspital  Lucerne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jarkko","family":"Piuhola","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine University of Oulu  Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi","family":"Lehtola","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine University of Oulu  Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Antonio","family":"Baz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Interventional Cardiology Unit University Hospital \u00c1lvaro Cunqueiro of Vigo  Pontevedra Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"I\u00f1iguez","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Interventional Cardiology Unit University Hospital \u00c1lvaro Cunqueiro of Vigo  Pontevedra Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lokien X.","family":"van Nunen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Catharina Hospital  Eindhoven Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pim A. L.","family":"Tonino","sequence":"additional","affiliation":[{"name":"Department of Cardiology Catharina Hospital  Eindhoven Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matti","family":"Niemel\u00e4","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine University of Oulu  Oulu Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7860-0298","authenticated-orcid":false,"given":"Stefan","family":"Toggweiler","sequence":"additional","affiliation":[{"name":"Heart Center Lucerne Luzerner Kantonsspital  Lucerne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.5603\/CJ.a2019.0019"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-18-00861"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs255"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV12I1A13"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.10.030"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-19-00331"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.07.032"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-17-00628"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.025103"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.10.052"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.03.023"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu162"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx294"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.29833","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.29833","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.29833","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T15:19:05Z","timestamp":1693149545000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.29833"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,17]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,11,15]]}},"alternative-id":["10.1002\/ccd.29833"],"URL":"https:\/\/doi.org\/10.1002\/ccd.29833","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,17]]},"assertion":[{"value":"2021-03-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}