{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T08:37:14Z","timestamp":1758271034938,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to evaluate the incidence, treatment, and outcomes of acute myocardial infarction (AMI) following transcatheter or surgical aortic valve replacement (TAVR or SAVR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Coronary artery disease is common in patients who undergo aortic valve replacement. However, little is known about differences in clinical features of post\u2010TAVR or post\u2010SAVR AMI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively identified post\u2010TAVR or post\u2010SAVR (including isolated and complex SAVR) patients admitted with AMI using the Nationwide Readmissions Database 2012\u20132017. Incidence, invasive strategy (coronary angiography or revascularization), and in\u2010hospital outcomes were compared between post\u2010TAVR and post\u2010SAVR AMIs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of 180\u2010day AMI was higher post\u2010TAVR than post\u2010SAVR (1.59% vs. 0.72%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Post\u2010TAVR AMI patients (n\u00a0=\u00a01315), compared with post\u2010SAVR AMI patients (n\u00a0=\u00a01344), were older, had more comorbidities and more frequent non\u2010ST\u2010elevation AMI (NSTEMI: 86.6% vs. 78.0%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). After propensity\u2010score matching, there was no significant difference in in\u2010hospital mortality between post\u2010TAVR and post\u2010SAVR AMIs (14.7% vs. 16.1%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.531), but the mortality was high in both groups, particularly in ST\u2010elevation AMI (STEMI: 38.8% vs. 29.2%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.153). Invasive strategy was used less frequently for post\u2010TAVR AMI than post\u2010SAVR AMI (25.6% vs. 38.3%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Invasive strategy was associated with lower mortality in both post\u2010TAVR (adjusted odds ratio\u00a0=\u00a00.40; 95% confidence interval\u00a0=\u00a0[0.24\u20130.66]) and post\u2010SAVR groups (0.60 [0.41\u20130.88]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AMI, albeit uncommon, was more frequent post\u2010TAVR than post\u2010SAVR. Patients commonly presented with NSTEMI, but the mortality of STEMI was markedly high. Further studies are needed to understand why a substantial percentage of patients do not receive invasive coronary treatment, particularly after TAVR, despite seemingly better outcomes with invasive strategy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29860","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T13:15:53Z","timestamp":1625750153000},"page":"877-888","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Incidence, treatment, and outcomes of acute myocardial infarction following transcatheter or surgical aortic valve replacement"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2172-6447","authenticated-orcid":false,"given":"Toshiaki","family":"Isogai","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine Heart, Vascular and Thoracic Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anas M.","family":"Saad","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart, Vascular and Thoracic Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keerat Rai","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart, Vascular and Thoracic Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shashank","family":"Shekhar","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart, Vascular and Thoracic Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8025-9212","authenticated-orcid":false,"given":"Omar M.","family":"Abdelfattah","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart, Vascular and Thoracic Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0218-3317","authenticated-orcid":false,"given":"Mohamed M.","family":"Gad","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart, Vascular and Thoracic Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars G.","family":"Svensson","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Heart, Vascular and Thoracic Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6048-7955","authenticated-orcid":false,"given":"Amar","family":"Krishnaswamy","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart, Vascular and Thoracic Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant W.","family":"Reed","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart, Vascular and Thoracic Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rishi","family":"Puri","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart, Vascular and Thoracic Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Murat","family":"Tuzcu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart, Vascular and Thoracic Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6239-9772","authenticated-orcid":false,"given":"Stephen G.","family":"Ellis","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart, Vascular and Thoracic Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0026-3391","authenticated-orcid":false,"given":"Samir R.","family":"Kapadia","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Heart, Vascular and Thoracic Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.06.012"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103510"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1400590"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1514616"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1700456"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1816885"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814052"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.09.001"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.119.008620"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.11.027"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.01.057"},{"key":"e_1_2_10_13_1","unstructured":"Healthcare Cost and Utilization Project.NRD Overview.https:\/\/www.hcup-us.ahrq.gov\/nrdoverview.jspAccessed June 5 2021."},{"key":"e_1_2_10_14_1","unstructured":"Healthcare Cost and Utilization Project.Requirements for Publishing with HCUP Data.https:\/\/www.hcup-us.ahrq.gov\/db\/publishing.jspAccessed June 5 2021."},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.119.007825"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.01.066"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.06.003"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.09.017"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.11.019"},{"key":"e_1_2_10_20_1","unstructured":"Centers for Medicare & Medicaid Services.ICD\u201010\u2010CM Official Guidelines for Coding and Reporting FY 2018https:\/\/www.cms.gov\/Medicare\/Coding\/ICD10\/Downloads\/2018\u2010ICD\u201010\u2010CM\u2010Coding\u2010Guidelines.pdf. 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