{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:41:29Z","timestamp":1747147289264,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T00:00:00Z","timestamp":1627948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients undergoing transcatheter edge\u2010to\u2010edge mitral valve repair (TEER) carry a high risk of rehospitalization due to disease, procedure, patient, hospital, and system related factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We aimed to explore the impact of gender on in\u2010hospital mortality and 90\u2010day readmissions in patients undergoing TEER.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We utilized the National Readmission Database from 2012 to 2018 to identify individuals who underwent TEER for mitral regurgitation. Gender\u2010based differences in in\u2010hospital mortality and 90\u2010day readmissions were explored using multivariable logistic regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 2012 and 2018, an estimated 21,415 TEER procedural hospitalizations were identified, of which 9893 (46.2%) were in women and 11,522 (53.8%) were in men. Compared with men, women were older, from a lower socioeconomic status but had a lower co\u2010morbidity burden. In\u2010hospital mortality rate during the index hospitalization was similar in women and men (2.1% vs. 2.1%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.908). Ninety\u2010day all\u2010cause and heart failure readmission rates were significantly higher in women compared to men (30.2% vs. 25.4%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 and 28.1% vs. 23.9%; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.020 respectively). In a multivariable analysis, women had 36% greater odds of 90\u2010day readmission compared to men (adjusted odds ratio [aOR] 1.36, 95% CI: 1.22\u20131.52; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Trend analysis revealed no significant improvement in rates of 90\u2010day readmission during the observation period for men or women (<jats:italic>p\u2009=<\/jats:italic>\u00a00.245, <jats:italic>p\u2009=<\/jats:italic>\u00a00.429, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Following TEER, there has been no significant improvement in 90\u2010day readmission rates between 2012 and 2018. Female gender is associated with higher 90\u2010day all\u2010cause and heart failure readmission rates.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29887","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T17:40:45Z","timestamp":1628012445000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of gender on in\u2010hospital mortality and 90\u2010day readmissions in patients undergoing transcatheter <scp>edge\u2010to\u2010edge<\/scp> mitral valve repair: Analysis from the National Readmission Database"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8740-2501","authenticated-orcid":false,"given":"Raviteja R.","family":"Guddeti","sequence":"first","affiliation":[{"name":"Division of Interventional Cardiology Minneapolis Heart Institute\/Abbott Northwestern Hospital  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1914-3998","authenticated-orcid":false,"given":"Venkata S.","family":"Pajjuru","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Creighton University School of Medicine  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan W.","family":"Walters","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Creighton University School of Medicine  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3715-8082","authenticated-orcid":false,"given":"Santiago A.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Division of Interventional Cardiology Minneapolis Heart Institute\/Abbott Northwestern Hospital  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkata M.","family":"Alla","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases Creighton University School of Medicine  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69208-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8191.2011.01274.x"},{"key":"e_1_2_10_4_1","first-page":"72","article-title":"2020 ACC\/AHA guideline for the Management of Patients with Valvular Heart Disease: a report of the American College of Cardiology\/American Heart Association joint committee on clinical practice guidelines","volume":"143","author":"Otto CM","year":"2021","journal-title":"Circulation"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28372"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.20000"},{"key":"e_1_2_10_7_1","first-page":"3","article-title":"Sex differences in clinical outcomes following percutaneous coronary intervention of unprotected left main coronary artery: A systematic review and meta\u2010analysis","volume":"20","author":"Thandra A","year":"2020","journal-title":"Cardiovasc Revasc Med"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.05.015"},{"key":"e_1_2_10_9_1","first-page":"42","article-title":"Gender differences in mitral valve surgery","volume":"61","author":"Seeburger J","year":"2013","journal-title":"Thorac Cardiovasc Surg"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2017.07.002"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsa0803563"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.11.050"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semtcvs.2018.07.017"},{"key":"e_1_2_10_14_1","unstructured":"NRD overview. 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