{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T05:50:07Z","timestamp":1769838607012,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T00:00:00Z","timestamp":1627948800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Cranio\u2010cervical artery dissection (CeAD) is a common cause of cerebrovascular events in young subjects with no clear treatment strategy established. We evaluated the incidence of major adverse cardiovascular events (MACE) in CeAD patients treated with and without stent placement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>COMParative effectiveness of treatment options in cervical Artery diSSection (COMPASS) is a single high\u2010volume center observational, retrospective longitudinal registry that enrolled consecutive CeAD patients over a 2\u2010year period. Patients were\u2009\u2265\u200918\u2009years of age with confirmed extra\u2010 or intracranial CeAD on imaging. Enrolled participants were followed for 1\u00a0year evaluating MACE as the primary endpoint.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One\u2010hundred ten patients were enrolled (age 53\u2009\u00b1\u200915.9, 56% Caucasian, and 50% male, BMI 28.9\u2009\u00b1\u20099.2). Grade I, II, III, and IV blunt vascular injury was noted in 16%, 33%, 19%, and 32%, respectively. Predisposing factors were noted in the majority (78%), including sneezing, carrying heavy load, chiropractic manipulation. Stent was placed in 10 (10%) subjects (extracranial carotid n\u00a0=\u00a09; intracranial carotid n\u00a0=\u00a01; extracranial vertebral n\u00a0=\u00a01) at the physician's discretion along with medical management. Reasons for stent placement were early development of high\u2010grade stenosis or expanding pseudoaneurysm. Stented patients experienced no procedural or in\u2010hospital complications and no MACE between discharge and 1\u2009year follow up. CeAD patients treated with medical management only had 14% MACE at 1\u2009year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this single high\u2010volume center cohort of CeAD patients, stenting was found to be beneficial, particularly with development of high\u2010grade stenosis or expanding pseudoaneurysm. These results warrant confirmation by a randomized clinical trial.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29890","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T15:40:30Z","timestamp":1628005230000},"page":"134-139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Stenting as a treatment for <scp>cranio\u2010cervical<\/scp> artery dissection: Improved major adverse cardiovascular event\u2010free survival"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3398-6430","authenticated-orcid":false,"given":"Alexandra","family":"Vezzetti","sequence":"first","affiliation":[{"name":"Department of Neurology, Radiology and Neurosurgery, Prisma Health Richland University of South Carolina School of Medicine  Columbia South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren M.","family":"Rosati","sequence":"additional","affiliation":[{"name":"Department of Neurology, Radiology and Neurosurgery, Prisma Health Richland University of South Carolina School of Medicine  Columbia South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Forrest J.","family":"Lowe","sequence":"additional","affiliation":[{"name":"Department of Neurology, Radiology and Neurosurgery, Prisma Health Richland University of South Carolina School of Medicine  Columbia South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Blease","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Neurology, Radiology and Neurosurgery, Prisma Health Richland University of South Carolina School of Medicine  Columbia South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roham","family":"Moftakhar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Radiology and Neurosurgery, Prisma Health Richland University of South Carolina School of Medicine  Columbia South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erwin","family":"Mangubat","sequence":"additional","affiliation":[{"name":"Department of Neurology, Radiology and Neurosurgery, Prisma Health Richland University of South Carolina School of Medicine  Columbia South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Souvik","family":"Sen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Radiology and Neurosurgery, Prisma Health Richland University of South Carolina School of Medicine  Columbia South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-019-0589-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)70018-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.2003.016774"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200103223441206"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0b013e318209ce03"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000088134"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000088157"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000509415"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000088166"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000024"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841850802133386"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2004.12.028"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2012.00724.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2016.07.087"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-004-0199-x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/7859719"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/s0317167100001724"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/bc.bc_19_20"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3171\/2011.2.FOCUS1139"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3171\/2015.10.JNS151846"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.29890","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.29890","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.29890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T06:00:18Z","timestamp":1693202418000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.29890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,3]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/ccd.29890"],"URL":"https:\/\/doi.org\/10.1002\/ccd.29890","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,3]]},"assertion":[{"value":"2021-05-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}