{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:57:56Z","timestamp":1787237876764,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016242","name":"Boston Scientific","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016242","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study was conducted to use optical coherence tomography (OCT) to compare vascular healing between bioresorbable polymer (BP) and durable polymer (DP) everolimus\u2010eluting stents (EES) in patients with acute coronary syndromes (ACS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Whether BP\u2010EES induce better vascular healing compared to contemporary DP\u2010EES remains controversial, especially for ACS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective, randomized, non\u2010inferiority trial, we used OCT to compare 6\u2010month vascular healing in patients with ACS randomized to BP versus DP\u2010EES: percent strut coverage (primary endpoint, non\u2010inferiority margin of 2.0%) and neointimal thickness and percent neointimal hyperplasia (NIH) volume. As an exploratory analysis, morphological factors related to the endpoints and the effect of underlying lipidic plaque on stent healing were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 104 patients with ACS were randomly assigned to BP\u2010EES (n\u00a0=\u00a052) versus DP\u2010EES (n\u00a0=\u00a052). Of these, 86 patients (40 BP\u2010EES and 46 DP\u2010EES) were included in the final OCT analyses. Six\u2010month percent strut coverage of BP\u2010EES (83.6\u2009\u00b1\u200911.4%) was not non\u2010inferior compared to those of DP\u2010EES (81.6\u2009\u00b1\u200913.9%), difference 2.0% (lower 95% confidence interval\u20102.6%),\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>non\u2010inferiority<\/jats:sub>\n                      \u00a0=\u00a00.07. There were no differences in neointimal thickness 70.0\u2009\u00b1\u200933.9\u00a0\u03bcm versus 67.2\u2009\u00b1\u200933.9\u00a0\u03bcm,\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u00a00.71; and percent NIH volume 7.5\u2009\u00b1\u20094.7% versus 7.3\u2009\u00b1\u20095.3%,\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u00a00.85. By multivariable linear regression analysis, stent type was not associated with percent strut coverage or percent NIH volume; however, percent baseline embedded struts or stent expansion was positively associated with percent NIH volume. Greater NIH volume was observed in lipidic compared with non\u2010lipidic segments (8.7\u2009\u00b1\u20095.6% vs. 6.1\u2009\u00b1\u20095.2%,\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u00a00.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Six\u2010month strut coverage of BP\u2010EES was not non\u2010inferior compared to those of DP\u2010EES in ACS patients. Good stent apposition and expansion were independently associated with better vascular healing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.29892","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T11:57:54Z","timestamp":1628251074000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of 6\u2010month vascular healing response after bioresorbable polymer versus durable polymer drug\u2010eluting stent implantation in patients with acute coronary syndromes: A randomized serial optical coherence tomography study"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4501-3449","authenticated-orcid":false,"given":"Masahiko","family":"Noguchi","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Biology and Medicine Juntendo University Graduate School of Medicine  Tokyo Japan"},{"name":"Clinical Trials Center 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