{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:36:10Z","timestamp":1786977370686,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005227","name":"Centers for Medicare and Medicaid Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005227","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U01 NS080165"],"award-info":[{"award-number":["U01 NS080165"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["U01 NS080168"],"award-info":[{"award-number":["U01 NS080168"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The multicenter prospective CREST\u20102 Registry (C2R) provides recent experience in performing carotid artery stenting (CAS) for interventionists to ensure safe performance of CAS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine the periprocedural safety of CAS performed using a transradial approach relative to CAS performed using a transfemoral approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with \u226570% asymptomatic and \u226550% symptomatic carotid stenosis, \u226480\u2009years of age and at standard or high risk for carotid endarterectomy (CEA) are eligible for the C2R. The primary endpoint was a composite of severe access\u2010related complications. Comparisons were made using propensity\u2010score matched logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age of the cohort was 67.6\u2009\u00b1\u20098.2\u2009years and 1906 (35.1%) were female. Indications for CAS included 4063 (74.9%) for primary atherosclerosis. A total of 2868 (52.8%) cases underwent CAS for asymptomatic disease. Transradial access was used in 213 (3.9%) patients. The transradial cohort had lower use of general anesthesia (1.5% vs. 6.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.007) and higher use of distal embolic protection (96.7% vs. 89.4%,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.0004). There were no significant differences between radial and femoral access groups in terms of a composite of major access\u2010related complications (0% vs. 1.1%) or a composite of periprocedural stroke or death (3.3% vs. 2.4%; OR\u00a0=\u00a01.4 [confidence intervals 0.6, 3.1];\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.42).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We found no significant differences in rates of major access\u2010related complications or periprocedural stroke or death with CAS performed using transradial compared to transfemoral access. Our results support incorporation of the transradial approach to clinical trials comparing CAS to other revascularization techniques.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.29912","type":"journal-article","created":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T02:59:31Z","timestamp":1628909971000},"page":"814-821","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Safety of the transradial approach to carotid stenting"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1571-6955","authenticated-orcid":false,"given":"Young","family":"Erben","sequence":"first","affiliation":[{"name":"Division of Vascular and Endovascular Surgery Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Meschia","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald V.","family":"Heck","sequence":"additional","affiliation":[{"name":"Department of Radiology Novant Health Forsyth Radiological Associates and Triad Radiology Associates  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fayaz A.","family":"Shawl","sequence":"additional","affiliation":[{"name":"Department of Medicine Washington Adventist\/White Oak Medical Center  Silver Spring Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minerva","family":"Mayorga\u2010Carlin","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery University of Maryland  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Howard","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, School of Public Health University of Alabama  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