{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T06:19:23Z","timestamp":1762409963432,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T00:00:00Z","timestamp":1628899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Diabetes mellitus (DM) is a predictor of restenosis and late stent thrombosis (ST) in patients undergoing percutaneous coronary intervention (PCI) with drug\u2010eluting\u2010stents (DES). Real\u2010world data on rates of early ST is lacking. We compared clinical outcomes of patients with and without DM from the Victorian cardiac outcomes registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients undergoing PCI with DES were analyzed with primary outcome being ST at 30\u2010days. Secondary outcomes including major adverse cardiovascular events (MACE) and all\u2010cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 43,209 patients included, 9730 (22.5%) had DM. At 30\u2009days, DM was independently associated with higher rates of early ST (0.7% vs. 0.5%) OR 1.41 (95% confidence interval; 1.05\u20131.87, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.02), MACE (4.1% vs. 3.5%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.004) and mortality (1.9% vs. 1.5%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.01). Increased risk was not simply due to treatment. Patients with DM requiring insulin were equally affected in regard to MACE (4.7% vs. 3.9%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.069) and mortality (1.9%, vs. 1.8%, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.746). On National Death Index linkage, patients with DM had increased all\u2010cause mortality over five\u2010year follow\u2010up (OR 1.69 CI 1.55\u20131.83, <jats:italic>p<\/jats:italic>\u00a0=\u00a0&lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this large real\u2010world\u2010registry, DM was an independent predictor of early ST, MACE and mortality at 30\u2009days. These data suggest additional therapeutic strategies are required to reduce the risk of early complications in patients with DM undergoing PCI with DES.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29913","type":"journal-article","created":{"date-parts":[[2021,8,14]],"date-time":"2021-08-14T07:56:14Z","timestamp":1628927774000},"page":"554-562","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Diabetes mellitus is independently associated with early stent thrombosis in patients undergoing drug eluting stent implantation: Analysis from the Victorian cardiac outcomes registry"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5024-0729","authenticated-orcid":false,"given":"Jason","family":"Nogic","sequence":"first","affiliation":[{"name":"Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash Health  Melbourne Victoria Australia"},{"name":"Department of Cardiology Eastern Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nitesh","family":"Nerlekar","sequence":"additional","affiliation":[{"name":"Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2008-9295","authenticated-orcid":false,"given":"Kean","family":"Soon","sequence":"additional","affiliation":[{"name":"Department of Cardiology Eastern Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Freeman","sequence":"additional","affiliation":[{"name":"Department of Cardiology Eastern Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmine","family":"Chan","sequence":"additional","affiliation":[{"name":"Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Cardiology Eastern Health  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Brennan","sequence":"additional","affiliation":[{"name":"Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diem","family":"Dinh","sequence":"additional","affiliation":[{"name":"Monash University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Lefkovits","sequence":"additional","affiliation":[{"name":"Department of Cardiology Royal Melbourne Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam 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