{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:29:54Z","timestamp":1756312194463,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T00:00:00Z","timestamp":1629590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007478","name":"Cardiovascular Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To compare 10\u2010year outcomes after implantation of sirolimus\u2010eluting stents (SES) versus paclitaxel\u2010eluting stents (PES) for left main coronary artery (LMCA) stenosis. Very long\u2010term outcome data of patients with LMCA disease treated with drug\u2010eluting stents (DES) have not been well described. In 10\u2010year extended follow\u2010up of the MAINCOMPARE registry, we evaluated 778 patients with unprotected LMCA stenosis who were treated with SES (<jats:italic>n<\/jats:italic>\u00a0=\u00a0607) or PES (<jats:italic>n<\/jats:italic>\u00a0=\u00a0171) between January 2000 and June 2006. The primary composite outcome (a composite of death, myocardial infarction [MI] or target\u2010vessel revascularization [TVR]) was compared with an inverse\u2010probability\u2010of\u2010treatment\u2010weighting (IPTW) adjustment. Clinical events have linearly accumulated over 10\u2009years. At 10\u2009years, there were no significant differences between SES and PES in the observed rates of the primary composite outcome (42.0% vs. 47.4%; hazard ratio [HR] 0.85; 95% confidence interval [CI] 0.66\u20131.10), and definite stent thrombosis (ST) (1.9% vs. 1.8%; HR 1.02, 95% CI 0.28\u20133.64). In the IPTW\u2010adjusted analyses, there were no significant differences between SES and PES in the risks for the primary composite outcome (HR 0.89, 95% CI 0.65\u20131.14) or definite ST (adjusted HR 1.05, 95% CI 0.29\u20133.90). In patients who underwent DES implantation, high overall adverse clinical event rates (with a linearly increasing event rate over time) were observed during extended follow\u2010up. At 10\u2009years, there were no measurable differences in outcomes between patients treated with SES vs. PES for LMCA disease. The incidence of stent thrombosis was quite low and comparable between the groups.<\/jats:p>","DOI":"10.1002\/ccd.29930","type":"journal-article","created":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T10:24:56Z","timestamp":1629627896000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ten\u2010year outcomes of early generation sirolimus\u2010 versus paclitaxel\u2010eluting stents in patients with left main coronary artery disease"],"prefix":"10.1002","volume":"98","author":[{"given":"Hanbit","family":"Park","sequence":"first","affiliation":[{"name":"Division of Cardiology, Gangneung Asan Hospital University of Ulsan College of Medicine  Gangneung Gangwon\u2010do South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do\u2010Yoon","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Center for Medical Research and Information, Asan Medical Center 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Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junho","family":"Hyun","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Center for Medical Research and Information, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pil Hyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Center for Medical Research and Information, Asan Medical Center University of Ulsan College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung\u2010Min","family":"Ahn","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Center for Medical Research and Information, Asan Medical Center University of Ulsan College of Medicine  Seoul South 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