{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T16:58:18Z","timestamp":1781024298952,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The current analysis utilized core laboratory angiographic data from a prospective, single\u2010arm, open\u2010label, multi\u2010center feasibility study to ascertain whether the location of alcohol infusion within main renal arteries during renal denervation (RDN) had an impact on the BP\u2010lowering effect at 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The influence of the location of alcohol infusion during RDN, within the main renal artery (proximal, middle, or distal), on the magnitude of the blood pressure (BP) lowering is unstudied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Peregrine Catheter was used to perform alcohol\u2010mediated RDN with an infusion of 0.6\u00a0mL of alcohol per artery as the neurolytic agent in 90 main arteries and four accessory arteries of 45 patients with hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No relationship between the site of alcohol infusion and change from baseline in both office systolic and 24\u2010hour systolic ambulatory BP (ABP) at 6\u00a0months was observed. When analyzed at the artery level, the least squares (LS) mean changes\u2009\u00b1\u2009SEM from baseline to 6\u00a0months post\u2010procedure in 24\u2010hour systolic ABP when analyzed by renal arterial location were \u221211.9\u2009\u00b1\u20092.4\u2009mmHg (distal), \u221210\u2009\u00b1 1.6\u2009mmHg (middle), and \u221210.6\u2009\u00b1\u20091.3\u2009mmHg (proximal) (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001 for change from baseline within groups). The results were similar for office systolic BP. There was no difference between treated locations (proximal is reference).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this post\u2010hoc analysis, the location of alcohol infusion within the main renal artery using the Peregrine system, with alcohol as the neurolytic agent for chemical RDN, did not affect the magnitude of BP changes at 6\u00a0months.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29936","type":"journal-article","created":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T11:35:26Z","timestamp":1630582526000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Blood pressure lowering with <scp>alcohol\u2010mediated<\/scp> renal denervation using the Peregrine infusion Catheter is independent of injection site location"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4425-549X","authenticated-orcid":false,"given":"Felix","family":"Mahfoud","sequence":"first","affiliation":[{"name":"Department of Internal Medicine III, Cardiology, Angiology, Intensive Care Medicine Saarland University Medical Center  Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Bertog","sequence":"additional","affiliation":[{"name":"Department of Medicine CardioVascular Center Frankfurt  Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1434-9556","authenticated-orcid":false,"given":"Lucas","family":"Lauder","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, Cardiology, Angiology, Intensive Care Medicine Saarland University Medical Center  Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"B\u00f6hm","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Innere Medizin III Saarland University Hospital  Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Schmid","sequence":"additional","affiliation":[{"name":"Institute of Radiology Universit\u00e4tsklinikum Erlangen  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wojciech","family":"Wojakowski","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Structural Heart Diseases Medical University of Silesia  Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Parise","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Medicine Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim A.","family":"Fischell","sequence":"additional","affiliation":[{"name":"Ablative Solutions, Inc.  Wakefield Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Kandzari","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Piedmont Heart Institute  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Pathak","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Princess Grace Hospital  Monaco Monaco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Persu","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Cliniques Universitaires Saint\u2010Luc and Pole of Cardiovascular Research, Institut de Recherche Exp\u00e9rimentale et Clinique Universit\u00e9 Catholique de Louvain  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horst","family":"Sievert","sequence":"additional","affiliation":[{"name":"Department of Medicine CardioVascular Center Frankfurt  Frankfurt Germany"},{"name":"Faculty of Medical Science Anglia Ruskin University  Chelmsford UK"},{"name":"University of California San Francisco UCSF  San Francisco California USA"},{"name":"Yunnan Hospital Fuwai  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30554-7"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31082-1"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.10.048"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.059"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.07.937"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.09.001"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.15106"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu450"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu192"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpu258"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.08.018"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2015.08.021"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-16-00206"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV9I1A20"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001160"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.12918"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-011-0346-8"},{"key":"e_1_2_10_19_1","first-page":"7(285)","article-title":"Arterial microanatomy determines the success of energy\u2010based renal denervation in controlling hypertension","volume":"29","author":"Tzafriri AR","year":"2015","journal-title":"Sci Transl med"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.037654"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.29936","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.29936","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.29936","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T15:19:30Z","timestamp":1693149570000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.29936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,2]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,11,15]]}},"alternative-id":["10.1002\/ccd.29936"],"URL":"https:\/\/doi.org\/10.1002\/ccd.29936","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,2]]},"assertion":[{"value":"2021-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}