{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T14:05:02Z","timestamp":1781273102627,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T00:00:00Z","timestamp":1631232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012367","name":"MedStar Health Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We sought to report details of the incidence, organisms, clinical course, and outcomes of prosthetic valve endocarditis (PVE) after transcatheter aortic valve replacement (TAVR) in low\u2010risk patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>PVE remains a rare but devastating complication of aortic valve replacement. Data regarding PVE after TAVR in low\u2010risk patients are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a detailed review of all patients in the low\u2010risk TAVR trials who underwent TAVR from 2016 to 2020 and were adjudicated to have definitive PVE by the independent Clinical Events Committee.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analyzed 396 low\u2010risk patients who underwent TAVR (including 72 with bicuspid valves). PVE occurred in 11 patients at a median 379\u2009days (210, 528) from TAVR. The incidence within the first 30\u2009days was 0%; days 31\u2013365, 1.5%; and after day 365, 2.8%. The most common organism identified was <jats:italic>Streptococcus<\/jats:italic> (<jats:italic>n<\/jats:italic>\u00a0=\u00a04\/11). Early PVE (\u2264 365\u2009days) occurred in five patients, of whom three demonstrated evidence of embolic stroke and two underwent surgical aortic valve re\u2010intervention. Late PVE (&gt; 365\u2009days) occurred in six patients, of whom thee demonstrated evidence of embolic stroke and only one underwent surgical aortic valve re\u2010intervention. Of the six patients with evidence of embolic stroke, two died, two were discharged to rehabilitation, and two were discharged home with home care.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PVE was infrequent following TAVR in low\u2010risk patients but was associated with substantial morbidity and mortality. Embolic stroke complicated the majority of PVE cases, contributing to worse outcomes in these patients. Efforts must be undertaken to minimize PVE in TAVR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29943","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T11:40:06Z","timestamp":1631274006000},"page":"896-903","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Prosthetic valve endocarditis after transcatheter aortic valve replacement in <scp>low\u2010risk<\/scp> patients"],"prefix":"10.1002","volume":"99","author":[{"given":"Giorgio A.","family":"Medranda","sequence":"first","affiliation":[{"name":"Section of Interventional Cardiology MedStar Washington Hospital Center  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toby","family":"Rogers","sequence":"additional","affiliation":[{"name":"Section of Interventional Cardiology MedStar Washington Hospital Center  Washington District of Columbia USA"},{"name":"Cardiovascular Branch, Division of Intramural Research, National Heart, Lung and Blood Institute National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed W.","family":"Ali","sequence":"additional","affiliation":[{"name":"Section of Interventional Cardiology MedStar Washington Hospital Center  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Section of Interventional Cardiology MedStar Washington Hospital Center  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corey","family":"Shea","sequence":"additional","affiliation":[{"name":"Section of Interventional Cardiology MedStar Washington Hospital Center  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn A.","family":"Sciandra","sequence":"additional","affiliation":[{"name":"Section of Interventional Cardiology MedStar Washington Hospital Center  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian C.","family":"Case","sequence":"additional","affiliation":[{"name":"Section of Interventional Cardiology MedStar Washington Hospital Center  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Forrestal","sequence":"additional","affiliation":[{"name":"Section of Interventional Cardiology MedStar Washington Hospital Center  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph A.","family":"Sutton","sequence":"additional","affiliation":[{"name":"Section of Interventional Cardiology MedStar Washington Hospital Center  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene P.","family":"McFadden","sequence":"additional","affiliation":[{"name":"Department of Cardiology Cork University Hospital  Cork Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prerna","family":"Malla","sequence":"additional","affiliation":[{"name":"Department of Neurology MedStar Washington Hospital Center  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Gordon","sequence":"additional","affiliation":[{"name":"Division of Cardiology Lifespan Cardiovascular Institute  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afshin","family":"Ehsan","sequence":"additional","affiliation":[{"name":"Division of Cardiothoracic Surgery Lifespan Cardiovascular Institute  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean R.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Medicine Valley Hospital  Ridgewood New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Levitt","sequence":"additional","affiliation":[{"name":"Department of Cardiology Henrico Doctors' Hospital  Richmond Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puja","family":"Parikh","sequence":"additional","affiliation":[{"name":"Department of Medicine Stony Brook Hospital  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bilfinger","sequence":"additional","affiliation":[{"name":"Department of Surgery Stony Brook Hospital  Stony Brook New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Torguson","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. Wiener Cardiovascular Institute Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1744-5271","authenticated-orcid":false,"given":"Federico M.","family":"Asch","sequence":"additional","affiliation":[{"name":"MedStar Health Research Institute MedStar Washington Hospital Center  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaby","family":"Weissman","sequence":"additional","affiliation":[{"name":"Department of Cardiology MedStar Washington Hospital Center  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itsik","family":"Ben\u2010Dor","sequence":"additional","affiliation":[{"name":"Section of Interventional Cardiology MedStar Washington Hospital Center  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian C.","family":"Shults","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery MedStar Washington Hospital Center  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5100-0471","authenticated-orcid":false,"given":"Hector M.","family":"Garcia\u2010Garcia","sequence":"additional","affiliation":[{"name":"Section of Interventional Cardiology MedStar Washington Hospital Center  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6446-2683","authenticated-orcid":false,"given":"Lowell F.","family":"Satler","sequence":"additional","affiliation":[{"name":"Section of Interventional Cardiology MedStar Washington Hospital Center  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4063-9226","authenticated-orcid":false,"given":"Ron","family":"Waksman","sequence":"additional","affiliation":[{"name":"Section of Interventional Cardiology MedStar Washington Hospital Center  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz588"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.041399"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.04.044"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.05.012"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.119.007938"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.12347"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2020.05.034"},{"key":"e_1_2_9_9_1","unstructured":"FDA expands indication for several transcatheter heart valves to patients at low risk for death or major complications associated with open\u2010heart surgery. 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