{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:41:40Z","timestamp":1747147300584,"version":"3.40.5"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,11,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives\/Background<\/jats:title><jats:p>Resting coronary blood flow approximates flow with maximal vasodilation in very severe coronary stenosis. We studied the incidence of exhausted vasodilatory reserve by FFR, its clinical characteristics and long\u2010term prognosis after FFR guided percutaneous coronary intervention (PCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients undergoing FFR\u2010guided PCI for coronary stenosis with reduced resting blood flow (baseline Pd\/Pa\u2009&lt;\u20090.8) were included. Basal maximal vasodilation (BMV) was defined as less than 5% difference between resting Pd\/Pa and FFR, that is, FFR\u2010baseline Pd\/Pa\u2009&lt; 0.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 658 vessels that underwent FFR\u2010guided PCI in 602 patients, 151 vessels had resting blood flow in the ischemic range (baseline Pd\/Pa \u2264 0.8) and were included in the analysis. Of these, 28 lesions in 28 patients met criteria for BMV (4.25% of the entire registry and 18.5% of those with the reduced basal coronary flow). Stenosis severity was a significant predictor of the presence of BMV. In long term follow\u2010up (median 106\u2009\u00b1\u20093.6\u00a0months), BMV was not associated with increased target vessel revascularization (TVR) or major adverse cardiac event compared to non\u2010BMV(OR 1.9, 95% CI 0.7\u20134.8, <jats:italic>p<\/jats:italic>\u2010value 0.2 and OR 1.3, 95% CI 0.75\u20132.5, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.3, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low baseline Pd\/Pa that approximates fractional flow reserve (exhausted vasodilatory reserve) defines a subgroup of patients with severe coronary artery stenosis. Prognosis, when treated with PCI along with medical therapy, appears similar to those with intact vasodilatory reserve.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.29945","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T16:41:34Z","timestamp":1631205694000},"page":"1021-1026","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exhaustion of coronary vasodilatory reserve in the resting state: Clinical characteristics and <scp>long\u2010term<\/scp> outcomes after intervention"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2404-1152","authenticated-orcid":false,"given":"Srikanth","family":"Vallurupalli","sequence":"first","affiliation":[{"name":"Division of Cardiology University of Arkansas for Medical Sciences  Little Rock Arkansas USA"},{"name":"Cardiology Section Central Arkansas Veterans Healthcare System  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Negar","family":"Salehi","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3176-4217","authenticated-orcid":false,"given":"Shiv","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Arkansas for Medical Sciences  Little Rock Arkansas USA"},{"name":"Cardiology Section Central Arkansas Veterans Healthcare System  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rimsha","family":"Hasan","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atif","family":"Hassan","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aisha","family":"Siraj","sequence":"additional","affiliation":[{"name":"Cardiology MetroHealth Medical Center  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Eid","family":"Madmani","sequence":"additional","affiliation":[{"name":"Division of Cardiology IU Health Ball Memorial Hospital  Muncie Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rahil","family":"Rafeedheen","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Ayan","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malek","family":"Al\u2010Hawwas","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Arkansas for Medical Sciences  Little Rock Arkansas USA"},{"name":"Cardiology Section Central Arkansas Veterans Healthcare System  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0099-2866","authenticated-orcid":false,"given":"Abdul","family":"Hakeem","sequence":"additional","affiliation":[{"name":"Division of Cardiology Rutgers University  New Brunswick New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9423-4702","authenticated-orcid":false,"given":"Barry F.","family":"Uretsky","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Arkansas for Medical Sciences  Little Rock Arkansas USA"},{"name":"Cardiology Section Central Arkansas Veterans Healthcare System  Little Rock Arkansas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.587196"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(74)90092-7"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.13.1257"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(96)00327-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.57.3.341"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406233302503"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.91.7.1944"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-305124"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0208612"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.09.002"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035837"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.08.004"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.050427"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.02.069"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.12.245"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.29945","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.29945","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.29945","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T15:18:58Z","timestamp":1693149538000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.29945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,9]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,11,15]]}},"alternative-id":["10.1002\/ccd.29945"],"URL":"https:\/\/doi.org\/10.1002\/ccd.29945","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"type":"print","value":"1522-1946"},{"type":"electronic","value":"1522-726X"}],"subject":[],"published":{"date-parts":[[2021,9,9]]},"assertion":[{"value":"2021-07-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}