{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:12:55Z","timestamp":1790496775495,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T00:00:00Z","timestamp":1633478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011953","name":"Abbott Medical Optics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011953","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016242","name":"Boston Scientific Japan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016242","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002336","name":"Daiichi Sankyo Company","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To identify the vulnerable diabetic cohort in patients undergoing transcatheter aortic valve replacement (TAVR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Backgrounds<\/jats:title>\n                    <jats:p>Considerable controversy remains about whether specific cohort exists in which presence of diabetes mellitus (DM) carries adverse risk of mortality after TAVR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Of the 2588 patients who were enrolled in the OCEAN\u2010TAVI registry, 2526 patients with glycohemoglobin data were analyzed. The individuals were divided into DM and non\u2010DM groups according to previous medical history of DM or using diabetic medicine, and increased HbA1c values (\u22656.5%) at baseline. The primary endpoint of this study was 2\u2010year all\u2010cause mortality after TAVR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The follow up rate of clinical outcome at 1\u2010year was 2514\/2526 (99.5%) and median follow\u2010up period was 22.5\u00a0months. DM group had 699 (27.7%) patients, in which 153 (21.9%) was diagnosed by increased HbA1c levels without previous medical history of DM. Kaplan\u2013Meier curve of 2\u2010year all\u2010cause mortality presented significant difference between patients with and without DM (\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u00a00.029). In addition, patients with low\u2010density lipoprotein cholesterol (LDL\u2010C) levels &gt; 100\u2009mg\/dl and left ventricular ejection fraction (LVEF)\u2009&lt;\u200940% had great risk of mortality after TAVR (LDL\u2010C: hazard ratio [HR] 1.82,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u20090.001; LVEF: HR 2.61,\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u00a00.002, respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Presence of DM was significantly associated with poor outcome after TAVR and adverse effect of DM was remarkable in patients with relatively higher LDL\u2010C levels and reduced LVEF under 40%. These subtypes may need intensive control of cardiovascular risk factors, including DM, before and after TAVR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.29960","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T10:05:09Z","timestamp":1633687509000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Impact of diabetes mellitus on outcome after transcatheter aortic valve replacement: Identifying high\u2010risk diabetic population from the\n                    <scp>OCEAN\u2010TAVI<\/scp>\n                    registry"],"prefix":"10.1002","volume":"98","author":[{"given":"Shingo","family":"Matsumoto","sequence":"first","affiliation":[{"name":"Department of Cardiology Tokai University School of Medicine  Isehara 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