{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:41:51Z","timestamp":1747147311766,"version":"3.40.5"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The ACURATE neo\u2122 is a novel, second\u2010generation self\u2010expanding supra\u2010annular transcatheter heart valve (THV). The objective of this multi\u2010centre registry is to assess the safety, clinical utility, and impact of \u2018learning\u2010curve\u2010experience\u2019 (LCE) on transcatheter aortic valve replacement outcomes in the United Kingdom (UK) and Ireland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively collected data from seven ACURATE neo\u2122 THV implanting centres (<jats:italic>n<\/jats:italic>\u00a0=\u00a0484) between February 2016 and November 2020. We compared mortality rates and outcomes in the LCE group (<jats:italic>n<\/jats:italic>\u00a0=\u00a0120) compared to next successive 120 cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the cohort was 81.9(SD: 6.1) years and the majority were in the moderate risk category (EuroSCORE\u2010II):3.3(SD: 3). The 97.5% of cases were performed under local anesthetic. The valve was successfully deployed in 98.8% of cases. The survival rate at 30\u2009days was 97.9%. The incidence of stroke was 2.5%. Life threatening bleeding occurred in 0.6% of cases and vascular access complications occurred in 21 (4.3%) patients. Implantation\u2010related conduction abnormalities occurred in 8.3% but only 5.6% required a PPM. The successful valve deployment occurred in 96% of the patients in the LCE group compared to 100% in the other group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.04; OR\u20102[CI 1.7\u20132.3]). The mortality rates at 30\u2009days (1.7% vs. 1.7%) and 1\u2009year (1.9% vs. 2.7%) were comparable between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study represents the largest published UK and Ireland real\u2010world experience of the ACURATE neo\u2122 valve. The procedural success rates and safety outcomes were excellent and endorse its utility in clinical practice. The LCE appears to have an impact on the successful valve deployment but without translating into short\u2010term or long\u2010term outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30000","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T15:40:31Z","timestamp":1637250031000},"page":"1172-1180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The impact of learning\u2010curve\u2010experience on transcatheter aortic valve replacement outcomes: Insights from the United Kingdom and Ireland all\u2010comers second\u2010generation <scp>ACURATE neo\u2122<\/scp> transcatheter aortic heart valve registry"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0814-0206","authenticated-orcid":false,"given":"Ashan","family":"Gunarathne","sequence":"first","affiliation":[{"name":"Trent Cardiac Centre University Hospital Nottingham NHS Trust  Nottingham 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Hospital Galway  Galway Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colum","family":"Owens","sequence":"additional","affiliation":[{"name":"Department of Cardiology Belfast Cardiac Centre, Royal Victoria Hospital  Belfast Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Spence","sequence":"additional","affiliation":[{"name":"Department of Cardiology Belfast Cardiac Centre, Royal Victoria Hospital  Belfast Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Cunnington","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospitals Leeds NHS Trust  Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Casserly","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospital Mater Misericordiae  Dublin 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