{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:28:48Z","timestamp":1793114928835,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the prognostic impact of baseline tricuspid annular plane systolic excursion\/pulmonary artery systolic pressure (TAPSE\/PASP) ratio, as an expression of the right ventricle\u2013pulmonary artery (RV\u2013PA)\u00a0coupling, in patients with mitral regurgitation (MR) treated with the MitraClip.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Impaired RV to PA coupling is considered a marker of RV dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From February 2016 to February 2020, a total of 165 patients were evaluated and stratified in two groups according to a prespecified value of TAPSE\/PASP ratio\u2009\u2264\u20090.36.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median patients' age was 79 (men: 62.4%). Sixty\u2010three patients (38.1%) presented TAPSE\/PASP\u2009\u2264\u20090.36 and were then compared with patients with TAPSE\/PASP\u2009&gt;\u20090.36. Functional MR etiology was more frequent in TAPSE\/PASP\u2009\u2264\u20090.36 (71.4%; <jats:italic>p<\/jats:italic>\u2009=\u20090.046). Acute technical success was achieved in 92.7% of the population, without any significant difference between the two groups of study and with sustained results at 30\u2010day (device success: 85.5%; procedural success: 84.8%).<\/jats:p><jats:p>On multivariate Cox regression analysis, after correction for body mass index, chronic kidney disease and left ventricle ejection fraction \u226530% but &lt;50%, TAPSE\/PASP\u2009\u2264\u20090.36 remained a sustained predictor of mortality and hospitalization for heart failure at one year after MitraClip (hazard ratio: 3.87; 95% confidence interval: 1.83\u20138.22; <jats:italic>p<\/jats:italic>\u2009\u2264\u20090.001). Kaplan\u2013Meier all\u2010cause mortality and heart failure hospitalization rates at one year were consequently higher in patients with TAPSE\/PASP\u2009\u2264\u20090.36 (39.4% vs. 14.8%; log\u2010rank <jats:italic>p<\/jats:italic>\u2009\u2264\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Baseline TAPSE\/PASP ratio seems independently associated with all\u2010cause mortality and heart failure hospitalization after MitraClip both in functional and degenerative MR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30044","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T21:59:11Z","timestamp":1640296751000},"page":"1277-1286","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Prognostic significance of right ventricle to pulmonary artery coupling in patients with mitral regurgitation treated with the MitraClip system"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2451-4626","authenticated-orcid":false,"given":"Antonio","family":"Popolo Rubbio","sequence":"first","affiliation":[{"name":"Department of Cardiology, IRCCS Policlinico San Donato San Donato Milanese  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4687-3686","authenticated-orcid":false,"given":"Luca","family":"Testa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, IRCCS Policlinico San Donato San Donato Milanese  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Granata","sequence":"additional","affiliation":[{"name":"Department of Cardiology, IRCCS Policlinico San Donato San Donato Milanese  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Salvatore","sequence":"additional","affiliation":[{"name":"Department of 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