{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:33:25Z","timestamp":1786977205157,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Our objective was to evaluate the impact of various blood pressures (BPs) on coronary perfusion and valvular hemodynamics following aortic valve replacement (AVR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lower systolic and diastolic (SBP\/DBP) pressures from the recommended optimal target range of SBP\u2009&lt;\u2009120\u2013130\u2009mmHg and DBP\u2009&lt;\u200980\u2009mmHg after AVR have been independently associated with increased cardiovascular and all\u2010cause mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The hemodynamic assessment of a 26\u2009mm SAPIEN 3 transcatheter aortic valve (TAV), 29\u2009mm Evolut R TAV, and 25\u2009mm Magna Ease surgical aortic valve (SAV) was performed in a pulsed left heart simulator with varying SBP, DBP, and heart rate (HR) conditions (60 and 120\u2009bpm) at 5\u2009L\/min cardiac output (CO). Average coronary flow (CF), effective orifice areas (EOAs), and valvulo\u2010arterial impedance (Zva) were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At HR of 60 bpm, at SBP\u2009&lt;\u2009120\u2009mmHg and DBP\u2009&lt;\u200960\u2009mmHg, CF decreased below the physiological lower limit with several different valves. Zva and EOA were found to increase and decrease respectively with increasing SBP and DBP. The same results were found with an HR of 120\u2009bpm. The trends of CF variation with BP were similar in all valves however the drop below the lower physiological CF limit was valve dependent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In a controlled in vitro system, with different aortic valve prostheses in place, CF decreased below the physiologic minimum when SBP and DBP were in the range targeted by blood pressure guidelines. Combined with recent observations from patients treated with AVR, these findings underscore the need for additional studies to identify the optimal BP in patients treated with AVR for AS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.30052","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T16:34:36Z","timestamp":1640190876000},"page":"1214-1224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Impact of blood pressure on coronary perfusion and valvular hemodynamics after aortic valve replacement"],"prefix":"10.1002","volume":"99","author":[{"given":"Brennan J.","family":"Vogl","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Michigan Technological University  Houghton Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef 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