{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T04:04:20Z","timestamp":1771992260489,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate the role of intracoronary pressure parameters in the assessment of viability in the myocardium subtending a significant coronary stenosis. In patients with ischemic left ventricular dysfunction, the presence of myocardial viability is related to the expected benefits derived from coronary revascularization. Intracoronary pressure wire\u2010based measurements were performed in 64 coronary lesions of \u226550% stenosis severity of 59 patients with postischemic left ventricular dysfunction, segmental left ventricular wall motion abnormalities, and substantial viability in the myocardial territory subtending the investigated stenotic coronaries, defined as the percent summed rest score in the target territory (%SRS<jats:sub>target<\/jats:sub>) \u226460% at the single\u2010photon emission tomography. Invasive pressure\u2010derived indexes like resting and hyperemic Pd\/Pa, \u0394Pd\/Pa, and %\u0394Pd\/Pa (defined as the absolute difference and percent decrease between resting and hyperemic Pd\/Pa respectively) were compared with %SRS<jats:sub>target<\/jats:sub>. A significant correlation was found between \u0394Pd\/Pa (Spearman's <jats:italic>p<\/jats:italic>: \u22120.760, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and %\u0394Pd\/Pa (<jats:italic>p<\/jats:italic>: \u22120.733; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) with %SRS<jats:sub>target.<\/jats:sub> These results were confirmed after correction for potential confounders. According to %SRS<jats:sub>target<\/jats:sub> median value, myocardial areas with high and low viability were compared: \u0394Pd\/Pa and %\u0394Pd\/Pa were significantly higher in areas with high viability (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 for both). According to receiver operating characteristic curves, we identified two cut\u2010offs (\u0394Pd\/Pa\u2009&gt;\u20090.11 and %\u0394Pd\/Pa\u2009&gt;\u200915%) able to predict &gt;80% viability with good sensitivity and specificity. Our study suggests that, in patients with postischemic left ventricular dysfunction and significant coronary stenosis, intracoronary pressures indexes like \u0394Pd\/Pa and %\u0394Pd\/Pa are able to predict the magnitude of downstream myocardial viability.<\/jats:p>","DOI":"10.1002\/ccd.30065","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T07:28:47Z","timestamp":1642577327000},"page":"271-279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intracoronary pressures to predict myocardial viability in patients with ischemic left ventricular dysfunction"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9216-5907","authenticated-orcid":false,"given":"Nicola","family":"Marchese","sequence":"first","affiliation":[{"name":"Unit of Cardiology Fondazione IRCCS Casa Sollievo della Sofferenza  San Giovanni Rotondo Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Barbato","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center OLV Hospital  Aalst Belgium"},{"name":"Department of Advanced Biomedical Sciences University Federico II  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Di Gioia","sequence":"additional","affiliation":[{"name":"Department of Advanced Biomedical Sciences University Federico II  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Stanislao","sequence":"additional","affiliation":[{"name":"Unit of Nuclear Medicine Fondazione IRCCS Casa Sollievo della Sofferenza  San Giovanni Rotondo Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Valle","sequence":"additional","affiliation":[{"name":"Unit of Nuclear Medicine Fondazione IRCCS Casa Sollievo della Sofferenza  San Giovanni Rotondo Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Copetti","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics Fondazione IRCCS Casa Sollievo della Sofferenza  San Giovanni Rotondo Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Pellegrini","sequence":"additional","affiliation":[{"name":"Unit of Statistical Sciences Alma Mater Studiorum University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Vigna","sequence":"additional","affiliation":[{"name":"Unit of Cardiology Fondazione IRCCS Casa Sollievo della Sofferenza  San Giovanni Rotondo Foggia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,1,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.87.4.1354"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199606273342604"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.08.055"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1205361"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408758"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0807611"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy812"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.104.2.157"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.05.019"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy394"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc0402.102975"},{"issue":"11","key":"e_1_2_8_14_1","first-page":"2127","article-title":"Operator\u2010less processing of myocardial perfusion SPECT studies","volume":"36","author":"Germano G","year":"1995","journal-title":"J Nucl Med"},{"issue":"4","key":"e_1_2_8_15_1","first-page":"712","article-title":"A new algorithm for the quantitation of myocardial perfusion SPECT. 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