{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T23:14:22Z","timestamp":1780096462045,"version":"3.54.0"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T00:00:00Z","timestamp":1641945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We describe the causes, timing and predictors of readmissions and analyze its impact on clinical outcomes in intermediate\u2010to\u2010high\u2010risk patients with severe symptomatic aortic stenosis (AS) who underwent transcatheter aortic valve replacement (TAVR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Intermediate\u2010high risk TAVR patients with severe AS have an increased risk for hospital readmissions due to the high burden of comorbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients who underwent TAVR from 2012 to 2018 at a single tertiary cardiac center were included and followed for 1 year. Readmissions were categorized as noncardiovascular (non\u2010CV) and CV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 611 patients (410 with no readmissions, 201 with \u22651 readmissions) were included. There was a total of 317 readmissions (mean: 1.58\u2009\u00b1\u20091.09 per readmitted patient) with 65 patients having \u22652 readmissions. 64.0% were non\u2010CV and 36.0% were CV. The top three CV causes were pacemaker\/implantable cardioverter\u2010defibrillator\u00a0placement, bleeding, and stroke. About 23% occurred at 1\u2009m, the majority were CV; 45% occurred between 7 and 12\u2009m, the majority were non\u2010CV. Those with \u22651 readmissions had a higher burden of comorbidities including peripheral arterial disease, diabetes, immunosuppression, prior percutaneous coronary interventions, and dialysis. Readmissions were associated with higher 1\u2010year mortality (adjusted hazard ratio: 2.53, 95% confidence interval: 1.40\u20134.59; <jats:italic>p<\/jats:italic>\u2009=\u20090.002). High\u2010risk patients had higher non\u2010CV readmissions (0.37\u2009\u00b1\u20090.79 vs. 0.25\u2009\u00b1\u20090.62; <jats:italic>p<\/jats:italic>\u2009=\u20090.044) compared to intermediate\u2010risk patients but similar CV readmissions (<jats:italic>p<\/jats:italic>\u2009=\u20090.645).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Understanding readmissions post\u2010TAVR will promote the early identification of at\u2010risk groups and the implementation of preventative measures to improve outcomes and reduce the burden and costs of readmissions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30066","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T11:30:11Z","timestamp":1641987011000},"page":"1188-1196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Understanding repeat hospitalizations in intermediate\u2010to\u2010high risk aortic stenosis patients following transcatheter aortic valve replacement"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7117-1833","authenticated-orcid":false,"given":"Andrew","family":"Chiou","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of California Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5227-8536","authenticated-orcid":false,"given":"Jonathan","family":"Yap","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of California Davis  California Davis USA"},{"name":"Department of Cardiology National Heart Centre Singapore  Singapore Singapore"},{"name":"Department of Cardiology Duke\u2010NUS Medical School  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of California Davis  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9404-751X","authenticated-orcid":false,"given":"Benjamin R.","family":"Stripe","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of California Davis  California Davis USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garrett B.","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of California Davis  California Davis USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Southard","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine University of California Davis  California Davis USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000047200.36165.B8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103510"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2011.164"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1514616"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814052"},{"key":"e_1_2_9_7_1","first-page":"479","article-title":"Frailty in patients undergoing transcatheter aortic valve replacement: from risk scores to frailty\u2010based management","volume":"18","author":"Tzoumas 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