{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:14:30Z","timestamp":1787663670707,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The relative merits of the drug\u2010coated balloon (DCB) versus uncoated balloon (UCB) angioplasty in endovascular intervention for patients with symptomatic lower extremity peripheral arterial disease (PAD) remains controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Online databases were queried with various combinations of keywords to identify relevant articles. Net adverse events (NAEs) and its components were compared using a random effect model to calculate unadjusted odds ratios (ORs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 26 studies comprising 26,845 patients (UCB: 17,770 and DCB: 9075) were included. On pooled analysis, DCB was associated with significantly lower odds of NAE (OR: 0.47, 95% confidence interval [CI]: 0.36\u20130.61), vessel restenosis (OR: 0.46, 95% CI: 0.37\u20130.57), major amputation (OR: 0.68, 95% CI: 0.47\u201399), need for repeat target lesion (OR: 0.38, 95% CI: 0.31\u20130.47) and target vessel revascularization\u00a0(OR: 0.62, 95% CI: 0.47\u20130.81) compared with UCB. Similarly, the primary patency rate was significantly higher in patients undergoing DCB angioplasty (OR: 1.44, 95% CI: 1.19\u20131.75), while the odds for all\u2010cause mortality (OR: 0.96, 95% CI: 0.85\u20131.09) were not significantly different between the two groups. A subgroup analysis based on follow\u2010up duration (6 months vs. 1\u00a0vs. 2 years) followed the findings of the pooled analysis with few exceptions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of DCB in lower extremity PAD intervention is associated with higher primary patency, lower restenosis, lower amputation rate, and decreased need for repeat revascularization with similar all\u2010cause mortality as compared to UCB.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30074","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T07:29:01Z","timestamp":1642577341000},"page":"1319-1326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Safety and efficacy of drug\u2010coated balloon for peripheral artery revascularization\u2014A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4850-0309","authenticated-orcid":false,"given":"Waqas","family":"Ullah","sequence":"first","affiliation":[{"name":"Department of Cardiology Thomas Jefferson University Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1521-332X","authenticated-orcid":false,"given":"Mohammad","family":"Zghouzi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Detroit Medical Center Heart Hospital Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeeshan","family":"Sattar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine SUNY Downstate Medical Center Brooklyn New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bachar","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Detroit Medical Center Heart Hospital Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2754-9397","authenticated-orcid":false,"given":"Salman","family":"Zahid","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rochester General Hospital Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4540-4741","authenticated-orcid":false,"given":"Abdul\u2010Rahman M.","family":"Suleiman","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Detroit Medical Center Heart Hospital Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1304-5748","authenticated-orcid":false,"given":"Yasar","family":"Sattar","sequence":"additional","affiliation":[{"name":"Department of Cardiology West Virginia University Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8473-8069","authenticated-orcid":false,"given":"Muhammad Zia","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Cardiology West Virginia University Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timir","family":"Paul","sequence":"additional","affiliation":[{"name":"Department of Cardiology The University of Tennessee Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1888-9429","authenticated-orcid":false,"given":"Rodrigo","family":"Bagur","sequence":"additional","affiliation":[{"name":"Department of Cardiology London Health Science Centre Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Imran","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Detroit Medical Center Heart Hospital Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9711-7616","authenticated-orcid":false,"given":"David L.","family":"Fischman","sequence":"additional","affiliation":[{"name":"Department of Cardiology Thomas Jefferson University Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhash","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9497-6706","authenticated-orcid":false,"given":"Anand","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Cardiology UT Health San Antonio San Antonio Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7874-4566","authenticated-orcid":false,"given":"M. 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