{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T02:40:39Z","timestamp":1768012839371,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study is to compare hemodynamic and echocardiographic findings between valve\u2010in\u2010valve (VIV) and native\u2010valve (NV) patients submitted to transcatheter aortic valve implantation (TAVI) due to pure aortic regurgitation (AR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with severe AR are surgically treated with variable postinterventional left\u2010ventricular (LV) \u201creverse remodeling.\u201d\u00a0TAVI might be considered in selected AR patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010eight patients with pure severe AR caused by either degenerated bioprosthesis or NV disease were successfully treated by TAVI at our institution. LV catheterization before and after TAVI and echocardiography before, after (24\u201372\u2009h), and at follow\u2010up (3\u201312 months) were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline clinical, hemodynamic, and echocardiographic characteristics were comparable between the two study groups, except for a younger age, higher proto\u2010diastolic LV pressure, and higher LV end\u2010systolic diameter in the NV group.\u00a0At catheterization, an immediate hemodynamic impact of TAVI in both groups was noticed, with a trend toward better postprocedural residual regurgitation index and significantly lower LV dP\/dT values (666.0\u2009\u00b1\u2009177.9 vs.\u00a0883.5\u2009\u00b1\u2009259.7\u2009mmHg\/s, <jats:italic>p<\/jats:italic>\u2009=\u20090.04) in VIV.\u00a0At echocardiography, both NV and VIV patients showed favorable (early and sustained) post\u2010TAVI echocardiographically detectable reverse remodeling. VIV patients also showed more pronounced early reduction in indexed LV end\u2010diastolic volume (68.1\u2009\u00b1\u200927.4\u00a0vs. 86.5\u2009\u00b1\u200928.9\u2009ml\/m<jats:sup>2<\/jats:sup> in VIV, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001\u00a0and 81.0\u2009\u00b1\u200929.0\u00a0vs. 95.2\u2009\u00b1\u200937.8\u2009ml\/m<jats:sup>2<\/jats:sup> in NV, <jats:italic>p<\/jats:italic>\u2009=\u20090.043).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Successful TAVI induces a striking hemodynamic impact with major structural (reverse remodeling) consequences in patients with pure AR caused by both bioprosthesis degeneration or NV disease. In the immediate postrelease phase, VIV patients might exhibit a more pronounced early LV contractile and structural benefit.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30082","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T07:28:04Z","timestamp":1642577284000},"page":"1599-1608","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Transcatheter aortic valve implantation in pure aortic regurgitation: Hemodynamic and echocardiographic findings in bioprosthesis vs.\u00a0native valve"],"prefix":"10.1002","volume":"99","author":[{"given":"Lazzaro","family":"Paraggio","sequence":"first","affiliation":[{"name":"Institute of Cardiology Fondazione Policlinico Universitario A. Gemelli IRCCS Roma Italia"},{"name":"Universit\u00e0 Cattolica del Sacro Cuore Roma Italia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6569-9401","authenticated-orcid":false,"given":"Francesco","family":"Burzotta","sequence":"additional","affiliation":[{"name":"Institute of Cardiology Fondazione Policlinico Universitario A. Gemelli IRCCS Roma Italia"},{"name":"Universit\u00e0 Cattolica del Sacro Cuore Roma Italia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Graziani","sequence":"additional","affiliation":[{"name":"Institute of Cardiology Fondazione Policlinico Universitario A. Gemelli IRCCS Roma Italia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Aurigemma","sequence":"additional","affiliation":[{"name":"Institute of Cardiology Fondazione Policlinico Universitario A. Gemelli IRCCS Roma Italia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1611-7708","authenticated-orcid":false,"given":"Enrico","family":"Romagnoli","sequence":"additional","affiliation":[{"name":"Institute of Cardiology Fondazione Policlinico Universitario A. Gemelli IRCCS Roma Italia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Pedicino","sequence":"additional","affiliation":[{"name":"Institute of Cardiology Fondazione Policlinico Universitario A. Gemelli IRCCS Roma Italia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Locorotondo","sequence":"additional","affiliation":[{"name":"Institute of Cardiology Fondazione Policlinico Universitario A. Gemelli IRCCS Roma Italia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica","family":"Mencarelli","sequence":"additional","affiliation":[{"name":"Institute of Cardiology Fondazione Policlinico Universitario A. Gemelli IRCCS Roma Italia"},{"name":"Universit\u00e0 Cattolica del Sacro Cuore Roma Italia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Lillo","sequence":"additional","affiliation":[{"name":"Institute of Cardiology Fondazione Policlinico Universitario A. Gemelli IRCCS Roma Italia"},{"name":"Universit\u00e0 Cattolica del Sacro Cuore Roma Italia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piergiorgio","family":"Bruno","sequence":"additional","affiliation":[{"name":"Institute of Cardiology Fondazione Policlinico Universitario A. 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