{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:22:43Z","timestamp":1780546963051,"version":"3.54.1"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T00:00:00Z","timestamp":1642896000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the effect of aging on coronary stenosis functional assessment with fractional flow reserve (FFR) and instantaneous wave\u2010free ratio (iFR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Limited data exist regarding the impact of patient age on these coronary pressure indices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 514 patients with coronary stenosis interrogated with intravascular physiology. The influence of patient age on FFR, iFR, and microcirculation\u2010related indices was investigated. Vessel\u2010oriented composite outcome (VOCO) was assessed in the FFR\u2010based deferred population according to iFR, coronary flow reserve (CFR), and age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FFR increased (<jats:italic>r<\/jats:italic>\u2009=\u20090.128, <jats:italic>p<\/jats:italic>\u2009=\u20090.004), iFR remained unchanged (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.001, <jats:italic>p<\/jats:italic>\u2009=\u20090.980), and CFR decreased (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.095, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) with patient age. Relationship between FFR and CFR differed across age groups (<jats:italic>r<\/jats:italic>\u2009=\u20090.263 in &lt;60 years old vs. <jats:italic>r<\/jats:italic>\u2009=\u20090.124 in \u226560 years old, <jats:italic>p<\/jats:italic>\u2009=\u20090.0056), whereas iFR correlated to CFR similarly regardless age (<jats:italic>r<\/jats:italic>\u2009=\u20090.283 in &lt;60 years old vs. <jats:italic>r<\/jats:italic>\u2009=\u20090.219 in \u226560 years old, <jats:italic>p<\/jats:italic>\u2009=\u20090.3781). No differences were found on angiographic stenosis severity (%DS 47.4 in &lt;60 years old and 49.8 in \u226560 years old, <jats:italic>p<\/jats:italic>\u2009=\u20090.317). At 5 years, FFR\u2010based revascularisation deferral in patients \u226560 years old was associated with more VOCO when either iFR (25%) or CFR (16.9%) were abnormal, compared to patients with normal iFR (6.3%) or normal CFR (4.6%) (log\u2010rank <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). This difference in clinical outcomes was not observed in younger patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FFR values increased progressively with patient age, potentially associated with age\u2010related changes in the coronary microcirculation. Conversely, iFR values remained unchanged across the patient age spectrum. In \u226560 years old patients with revascularisation deferral based on FFR, both abnormal iFR and CFR values were associated with worse long\u2010term patient outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30092","type":"journal-article","created":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T20:33:55Z","timestamp":1642970035000},"page":"1104-1114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association between patient age, microcirculation, and coronary stenosis assessment with fractional flow reserve and instantaneous wave\u2010free ratio"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1030-1926","authenticated-orcid":false,"given":"Hernan","family":"Mejia\u2010Renteria","sequence":"first","affiliation":[{"name":"Hospital Clinico San Carlos IDISCC Complutense University of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Faria","sequence":"additional","affiliation":[{"name":"Hospital Clinico San Carlos IDISCC Complutense University of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2178-4014","authenticated-orcid":false,"given":"Joo Myung","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2337-7826","authenticated-orcid":false,"given":"Seung Hun","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Heart Vascular Stroke Institute, Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 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Medicine Ulsan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3661-1914","authenticated-orcid":false,"given":"Masahiro","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyo","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Kanaji","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine Tsuchiura Kyodo General Hospital Ibaraki 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