{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:31:33Z","timestamp":1762918293701,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T00:00:00Z","timestamp":1645228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The study aimed to evaluate cost trends associated with mitral valve transcatheter edge\u2010to\u2010edge repair (TEER).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>TEER is a treatment option for patients at prohibitive surgical risk with moderate to severe mitral valve regurgitation and NYHA class III or IV symptoms. The 30\u2010day costs and causes of readmission following TEER have not been well studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients undergoing mitral TEER in the United States from 2014 to 2018 were identified in the Nationwide Readmission Database. Patient characteristics, cause\u2010specific readmission, and costs of the index hospitalization and readmissions were analyzed. Costs were trended over years using general linear regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 10,196 patients underwent mitral TEER during the study period. Thirty\u2010day readmissions were stable over time at around 16%. The mean length of stay following TEER decreased from 7 days in 2014 to 5 days in 2018. There was a significant decline in the cost of the index hospitalization of $1311 per year, and a significant decline in the total 30\u2010day cost of $1588 per year (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). This was strictly due to a reduction in the cost of the index hospitalization without a change in readmission costs over time (<jats:italic>p<\/jats:italic>\u2009=\u20090.23). Infectious causes of readmissions significantly decreased while total cardiovascular readmissions, including heart failure, remained constant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The decreasing 30\u2010day cost burden of TEER is primarily driven by the shorter index length of stay, as experience in TEER has grown and, length of stay has declined. However, cardiovascular readmissions, and consequently readmission costs, have remained steady.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30121","type":"journal-article","created":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T08:43:58Z","timestamp":1645260238000},"page":"1251-1256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Five\u2010year trends in cause\u2010specific readmissions and cost burden of mitral transcatheter edge\u2010to\u2010edge repair"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7658-2348","authenticated-orcid":false,"given":"Nicholas","family":"Fabry","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University of North Carolina School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5350-3320","authenticated-orcid":false,"given":"Michael J.","family":"Hendrickson","sequence":"additional","affiliation":[{"name":"University of North Carolina School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6387-3015","authenticated-orcid":false,"given":"Sameer","family":"Arora","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of North Carolina School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Vavalle","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of North Carolina School of Medicine  Chapel Hill North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,19]]},"reference":[{"issue":"88","key":"e_1_2_7_2_1","first-page":"i3","article-title":"Percutaneous mitral valve interventions (repair): current indications and future perspectives","volume":"6","author":"Shah M","year":"2019","journal-title":"Front Cardiovasc Med"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1806640"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009355"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000503"},{"key":"e_1_2_7_6_1","unstructured":"JensenTS ChinJ FarmerSA et al.\u00a0Decision Memo for Transcatheter Mitral Valve Repair (TMVR) (CAG\u201000438R). January 19 2021.\u00a0www.cms.gov\/medicare-coverage-database\/details\/nca-decision-memo.aspx?NCAId=297"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2020.04.004"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.27366"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjqcco\/qcx049"},{"key":"e_1_2_7_10_1","unstructured":"NRD Overview.Healthcare Cost and Utilization Project (HCUP). 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