{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T14:35:44Z","timestamp":1782657344901,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:00:00Z","timestamp":1647820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to describe stroke and transient ischemic attacks (TIAs) after transcatheter aortic valve replacement (TAVR) and to identify associated risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Stroke\/TIA after TAVR is a major complication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1919 concomitant patients underwent TAVR in a single center from 2007 to 2017. Pre\u2010, intra\u2010, and postprocedural data were collected prospectively in a database and analyzed retrospectively. Stroke and TIA were documented according to the Valve Academic Research Consortium\u2010II criteria. Logistic regression was used to determine risk factors for stroke after TAVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean age was 79.5\u2009\u00b1\u20096.8 years, mean logistic EuroScore was 17.6%\u2009\u00b1\u200912.8%, and 51.8% (<jats:italic>n<\/jats:italic>\u2009=\u2009994) of the patients were female. Stroke\/TIA occurred in 76 patients (3.9%), 1.9% were disabling, and 1.6% nondisabling. The predominant type of stroke were territorial ischemic lesions (82.4%), with primary bleeding in 4.4% and border zone infarctions in 4.4%. Left\u2010sided lesions were more common (45.6% left sided vs. 25% right sided) and 13.2% of the lesions were bilateral (4.4% no finding and 11.8% missing data). In multivariate logistic regression, prior stroke (odds ratio [OR]\u2009=\u20091.83, <jats:italic>p<\/jats:italic>\u2009=\u20090.046) and initial experience (first 300 TAVR implanted at our center) were identified as independent risk factors for stroke\/TIA during the first 30 days (OR\u2009=\u20091.95, <jats:italic>p<\/jats:italic>\u2009=\u20090.045). Overall, the occurrence of stroke had a highly significant impact on a 30\u2010day mortality (13.2% vs. 4.9% in patients without stroke (<jats:italic>p<\/jats:italic>\u2009=\u20090.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Stroke within the first 30 days after TAVR severely impairs 30\u2010day survival. We identified prior stroke and initial experience as significant independent risk factors for the occurrence of stroke after TAVR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30143","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T12:33:10Z","timestamp":1647865990000},"page":"1897-1905","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Stroke after transcatheter aortic valve replacement: A severe complication with low predictability"],"prefix":"10.1002","volume":"99","author":[{"given":"Lena K.","family":"Eschenbach","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, German Heart Centre Munich Technische Universit\u00e4t M\u00fcnchen Germany"},{"name":"Department of Cardiovascular Surgery, German Heart Centre Munich, Insure (Institute for Translational Cardiac Surgery) Technische Universit\u00e4t M\u00fcnchen Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Erlebach","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, German Heart Centre Munich Technische Universit\u00e4t M\u00fcnchen Germany"},{"name":"Department of Cardiovascular Surgery, German Heart Centre Munich, Insure (Institute for Translational Cardiac Surgery) Technische Universit\u00e4t M\u00fcnchen Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus\u2010Andr\u00e9","family":"Deutsch","sequence":"additional","affiliation":[{"name":"Clinic for Thoracic and Cardiovascular Surgery, Herz\u2010und Diabeteszentrum Nordrhein\u2010Westfalen Ruhr\u2010Universit\u00e4t Bochum Bad Oeynhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Ruge","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, German Heart Centre Munich Technische Universit\u00e4t M\u00fcnchen Germany"},{"name":"Department of Cardiovascular Surgery, German Heart Centre Munich, Insure (Institute for Translational Cardiac Surgery) Technische Universit\u00e4t M\u00fcnchen Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Bleiziffer","sequence":"additional","affiliation":[{"name":"Clinic for Thoracic and Cardiovascular Surgery, Herz\u2010und Diabeteszentrum Nordrhein\u2010Westfalen Ruhr\u2010Universit\u00e4t Bochum Bad Oeynhausen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Holzer","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, German Heart Centre Munich Technische Universit\u00e4t M\u00fcnchen Germany"},{"name":"Department of Cardiovascular Surgery, German Heart Centre Munich, Insure (Institute for Translational Cardiac Surgery) Technische Universit\u00e4t M\u00fcnchen Munich 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruediger","family":"Lange","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, German Heart Centre Munich Technische Universit\u00e4t M\u00fcnchen Germany"},{"name":"Department of Cardiovascular Surgery, German Heart Centre Munich, Insure (Institute for Translational Cardiac Surgery) Technische Universit\u00e4t M\u00fcnchen Munich Germany"},{"name":"DZHK (German Centre for Cardiovascular Research)\u2013Partner site Munich Heart Alliance Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melchior","family":"Burri","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, German Heart Centre Munich Technische Universit\u00e4t M\u00fcnchen Germany"},{"name":"Department of Cardiovascular Surgery, German Heart Centre Munich, Insure (Institute for Translational Cardiac Surgery) Technische Universit\u00e4t M\u00fcnchen Munich 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