{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T10:14:29Z","timestamp":1756635269739,"version":"3.37.3"},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:00:00Z","timestamp":1647820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare outcomes in Sapien 3 Ultra (S3U) transcatheter aortic valve replacement (TAVR) with extreme annular undersizing (EAU) versus nominal annular sizing (NAS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The Edwards S3U\u00a0valve has reduced paravalvular leak (PVL) in TAVR but outcomes remain unknown in extremely undersized anatomy. Implanting a smaller S3U valve may facilitate future redo\u2010TAVR but risk compromising hemodynamics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From December 2019 to July 2021, 366 patients with native aortic stenosis underwent S3U TAVR. Patients with EAU (annular areas &gt;430\u2009mm<jats:sup>2<\/jats:sup> for 23\u2009mm or &gt;546\u2009mm<jats:sup>2<\/jats:sup> for 26\u2009mm) were compared to NAS (338\u2013430\u2009mm<jats:sup>2<\/jats:sup> for 23\u2009mm or 430\u2013546\u2009mm<jats:sup>2<\/jats:sup> for 26\u2009mm). In\u2010hospital and 30\u2010day outcomes, and redo\u2010TAVR feasibility were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 79 (21.6%) EAU patients, with more bicuspid\u00a0(<jats:italic>p<\/jats:italic>\u2009=\u20090.0014) and \u2265moderate annular\/left ventricular outflow tract\u00a0calcification (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The EAU group had less annular oversizing than NAS group (23\u2009mm: \u22128.2\u2009\u00b1\u20092.6% vs. 4.0\u2009\u00b1\u20097.0%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; 26\u2009mm: \u22128.9\u2009\u00b1\u20092.2% vs. 6.7\u2009\u00b1\u20096.9%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), more balloon overfilling (71.3% vs. 11.6%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and postdilatation (15.0% vs. 5.8%, <jats:italic>p<\/jats:italic>\u2009=\u20090.016). No differences were found in in\u2010hospital or 30\u2010day mortality and stroke (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Mild PVL (13.4% EAU vs. 11.5% NAS, <jats:italic>p<\/jats:italic>\u2009=\u20090.56) and mean gradients (23\u2009mm: 13.0\u2009\u00b1\u20094.5 vs. 14.1\u2009\u00b1\u20095.4\u2009mmHg, <jats:italic>p<\/jats:italic>\u2009=\u20090.40; 26\u2009mm: 11.4\u2009\u00b1\u20094.1 vs. 11.5\u2009\u00b1\u20093.9\u2009mmHg, <jats:italic>p<\/jats:italic>\u2009=\u20091.0) were similar at 30 days. Had the EAU group undergone NAS with the larger Sapien 3\/S3U, by computed tomography analysis simulating 80:20 or 90:10 target implant depth, 33.3%\u201360.9% (vs. 4.3%\u201323.2%) would not be feasible for redo\u2010TAVR due to high risk of coronary obstruction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this first report of EAU with S3U TAVR, similar excellent short\u2010term outcomes can be achieved compared to NAS, and may preserve future redo\u2010TAVR option.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30146","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T12:36:02Z","timestamp":1647866162000},"page":"1935-1944","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Outcomes and feasibility of redo\u2010TAVR after Sapien 3 Ultra TAVR in extremely\u2010undersized\u00a0versus nominally\u2010sized annuli"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7219-990X","authenticated-orcid":false,"given":"Gilbert H. L.","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery Mount Sinai Health System New York City New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Hooda","sequence":"additional","affiliation":[{"name":"Division of Cardiology Mount Sinai Hospital New York City New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9426-3618","authenticated-orcid":false,"given":"Syed","family":"Zaid","sequence":"additional","affiliation":[{"name":"Division of Cardiology Houston Methodist DeBakey Heart and Vascular Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Yu","family":"Chuang","sequence":"additional","affiliation":[{"name":"Division of Cardiology St. Paul's Hospital Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahil","family":"Khera","sequence":"additional","affiliation":[{"name":"Division of Cardiology Mount Sinai Hospital New York City New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parasuram","family":"Krishnamoorthy","sequence":"additional","affiliation":[{"name":"Division of Cardiology Mount Sinai Hospital New York City New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stamatios","family":"Lerakis","sequence":"additional","affiliation":[{"name":"Division of Cardiology Mount Sinai Hospital New York City New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malcolm","family":"Anastasius","sequence":"additional","affiliation":[{"name":"Division of Cardiology Mount Sinai Hospital New York City New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan A.","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Section of Cardiothoracic Surgery Westchester Medical Center Valhalla New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua B.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Section of Cardiothoracic Surgery Westchester Medical Center Valhalla New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariama","family":"Akodad","sequence":"additional","affiliation":[{"name":"Division of Cardiology St. Paul's Hospital Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Wood","sequence":"additional","affiliation":[{"name":"Division of Cardiology St. Paul's Hospital Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathon A.","family":"Leipsic","sequence":"additional","affiliation":[{"name":"Department of Radiology St. Paul's Hospital Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Blanke","sequence":"additional","affiliation":[{"name":"Division of Cardiology Houston Methodist DeBakey Heart and Vascular Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7502-8049","authenticated-orcid":false,"given":"George D.","family":"Dangas","sequence":"additional","affiliation":[{"name":"Division of Cardiology Mount Sinai Hospital New York City New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samin K.","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Cardiology Mount Sinai Hospital New York City New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7189-3307","authenticated-orcid":false,"given":"Annapoorna S.","family":"Kini","sequence":"additional","affiliation":[{"name":"Division of Cardiology Mount Sinai Hospital New York City New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G.","family":"Webb","sequence":"additional","affiliation":[{"name":"Division of Cardiology St. Paul's Hospital Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9513-9440","authenticated-orcid":false,"given":"Janarthanan","family":"Sathananthan","sequence":"additional","affiliation":[{"name":"Division of Cardiology St. Paul's Hospital Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.12.052"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1816885"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.07.013"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.29281"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002947"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.03.034"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.08.042"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.02.020"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.09.022"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.02.038"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.30146","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.30146","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.30146","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T08:39:40Z","timestamp":1692607180000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.30146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,21]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1002\/ccd.30146"],"URL":"https:\/\/doi.org\/10.1002\/ccd.30146","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"type":"print","value":"1522-1946"},{"type":"electronic","value":"1522-726X"}],"subject":[],"published":{"date-parts":[[2022,3,21]]},"assertion":[{"value":"2021-12-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}