{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:44:39Z","timestamp":1787611479425,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of the study was to analyze available data on patients treated for chronic limb\u2010threatening ischemia (CLTI) with the heparin\u2010bonded Viabahn endoprosthesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The patency of self\u2010expanding covered stents in patients with complex femoropopliteal lesions is encouraging. However, data were mostly derived in patients with intermittent claudication. Patients with CLTI often have more advanced disease and worse outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After the abstract screening, full\u2010text papers were checked. Authors were approached to consider joining the consortium. Data were sent anonymously, databases were merged and an individual patient data meta\u2010analysis was performed. Kaplan\u2013Meier curves were used to calculate the freedom from amputations, the amputation\u2010free survival, and patency rates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven studies were enrolled, representing 161 limbs that were treated for CLTI. Median lesion length was 28.0\u2009cm (interquartile range 25.0\u201333.0\u2009cm) and 82.7% were chronic total occlusions. The technical success rate was 98.1% and the 30\u2010day mortality 1.9%. Through 2\u2010year follow\u2010up, the freedom\u2010from\u2010major\u2010amputations was 99.3%, with an amputation\u2010free survival of 78.8%. The freedom\u2010from\u2010loss\u2010of primary, primary\u2010assisted, and secondary patency was 70.4%, 71.8%, and 88.2%, respectively, at 1\u2010year and 59.5%, 62.7%, and 86.1% at 2\u2010year follow\u2010up, respectively. The reintervention\u2010free survival was 62.2% at a 2\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment of femoropopliteal disease in CLTI patients with the use of the heparin\u2010bonded Viabahn is safe and effective with favorable clinical outcomes and low amputation rates. Reinterventions are needed in a subset of the population to maintain endoprosthesis patency. Close follow\u2010up using duplex is recommended to detect potential edge stenosis, allowing treatment before device occlusion.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30152","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T09:09:08Z","timestamp":1646644148000},"page":"1714-1722","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Individual patient data meta\u2010analysis of patients treated with a heparin\u2010bonded Viabahn in the femoropopliteal artery for chronic limb\u2010threatening ischemia"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7041-8603","authenticated-orcid":false,"given":"Erik","family":"Groot Jebbink","sequence":"first","affiliation":[{"name":"Department of Surgery Rijnstate  Arnhem The Netherlands"},{"name":"Multi\u2010Modality Medical Imaging Group, TechMed Center University of Twente  Enschede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"van Wijck","sequence":"additional","affiliation":[{"name":"Department of Surgery Rijnstate  Arnhem The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Holewijn","sequence":"additional","affiliation":[{"name":"Department of Surgery Rijnstate  Arnhem The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6829-7304","authenticated-orcid":false,"given":"Osamu","family":"Iida","sequence":"additional","affiliation":[{"name":"Cardiovascular Center, Kansai Rosai Hospital  Amagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Spinelli","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Dental Sciences and Morphological and Functional Imaging University of Messina  Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Saxon","sequence":"additional","affiliation":[{"name":"Interventional Radiology San Diego Medical Imaging Group, Inc.  San Diego USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2704-3871","authenticated-orcid":false,"given":"Thomas","family":"Zeller","sequence":"additional","affiliation":[{"name":"Department Angiology Universit\u00e4ts\u2010Herzzentrum Freiburg\u2010Bad Krozingen  Bad Krozingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Okhi","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Bosiers","sequence":"additional","affiliation":[{"name":"Foundation for Cardiovascular Research and Education  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5021-1768","authenticated-orcid":false,"given":"Michel M. P. 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