{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:50:00Z","timestamp":1781880600779,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T00:00:00Z","timestamp":1647302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The purpose of this study is to investigate the viability of transcatheter aortic valve replacement (TAVR) for severe symptomatic aortic stenosis (AS) in patients with prior chest radiation therapy (cXRT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Since patients with prior cXRT perform poorly with surgical aortic valve replacement, TAVR can be a viable alternative. However, clinical outcomes after TAVR in this patient population have not been well studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From the pooled registry of the placement of aortic transcatheter valves\u00a0II trial, we identified patients with and without prior cXRT who underwent TAVR (<jats:italic>n<\/jats:italic>\u2009=\u200964 and 3923, respectively). The primary outcome was a composite of all\u2010cause death and any stroke at 2 years. Time to event analyses were shown as Kaplan\u2013Meier event rates and compared by log\u2010rank testing. Hazard ratios (HRs) were estimated and compared by Cox proportional hazards regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference in the primary outcome between the patients with and without prior cXRT (30.7% vs. 27.0%; <jats:italic>p<\/jats:italic>\u2009=\u20090.75; HR, 1.08; 95% confidence interval, 0.66\u20131.77). Rates of myocardial infarction, vascular complications, acute kidney injury, or new pacemaker implant after TAVR were not statistically different between the two groups. The rate of immediate reintervention with a second valve for aortic regurgitation after TAVR was higher among the patients with prior cXRT. However, no further difference was observed during 2 years follow\u2010up after discharge from the index\u2010procedure hospitalization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TAVR is a viable alternative for severe symptomatic AS in patients who had cXRT in the past.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30154","type":"journal-article","created":{"date-parts":[[2022,3,15]],"date-time":"2022-03-15T09:11:45Z","timestamp":1647335505000},"page":"1877-1885","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Characteristics and clinical outcomes in patients with prior chest radiation undergoing TAVR: Observations from PARTNER\u20102"],"prefix":"10.1002","volume":"99","author":[{"given":"Bibhu D.","family":"Mohanty","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Sciences, Morsani College of Medicine University of South Florida Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Coylewright","sequence":"additional","affiliation":[{"name":"Department of Cardiology Erlanger Health System Chattanooga Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9979-4167","authenticated-orcid":false,"given":"Ashton R.","family":"Sequeira","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine,Morsani College of Medicine University of South Florida Tampa Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4960-5732","authenticated-orcid":false,"given":"Doosup","family":"Shin","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases University of Iowa Hospitals and Clinics Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangbo","family":"Liu","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ditian","family":"Li","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fradley","sequence":"additional","affiliation":[{"name":"Cardio\u2010Oncology Program, Division of Cardiovascular Medicine, Department of Medicine University of Pennsylvania Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Alu","sequence":"additional","affiliation":[{"name":"Structural Heart and Valve Center, NewYork\u2010Presbyterian Hospital Columbia University Irving Medical Center New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Mack","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery Service Baylor Scott &amp; White Healthcare Plano Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir R.","family":"Kapadia","sequence":"additional","affiliation":[{"name":"Department of Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susheel","family":"Kodali","sequence":"additional","affiliation":[{"name":"Structural Heart and Valve Center, NewYork\u2010Presbyterian Hospital Columbia University Irving Medical Center New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod H.","family":"Thourani","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Piedmont Heart Institute Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj R.","family":"Makkar","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Division Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin B.","family":"Leon","sequence":"additional","affiliation":[{"name":"Structural Heart and Valve Center, NewYork\u2010Presbyterian Hospital Columbia University Irving Medical Center New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Malenka","sequence":"additional","affiliation":[{"name":"Division of Cardiology Dartmouth\u2010Hitchcock Medical Center Lebanon New Hampshire 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