{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:11:37Z","timestamp":1771233097747,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:00:00Z","timestamp":1647820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to compare indirect mitral annuloplasty using the Carillon Mitral Contour System and edge\u2010to\u2010edge repair via MitraClip in atrial functional mitral regurgitation (aFMR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>In patients with left ventricular dilation, both edge\u2010to\u2010edge repair and indirect mitral annuloplasty are effective in reducing mitral regurgitation, while no clinical trial has compared both interventional methods in aFMR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a retrospective single\u2010center analysis, 41 patients with aFMR underwent either edge\u2010to\u2010edge mitral valve repair (MitraClip group, <jats:italic>n<\/jats:italic>\u2009=\u200920) or indirect annuloplasty (Carillon group, <jats:italic>n<\/jats:italic>\u2009=\u200921).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both treatment groups showed high procedural success (100%) and low complication rates. Both treatment groups showed a comparable reduction of New York Heart Association (NYHA) classification postimplantation, after 3\u2010 and 12\u2010months follow\u2010up. Quantitative reduction in echocardiographic FMR parameters was significantly pronounced in the MitraClip group (reduction in vena contracta MitraClip vs. Carillon: postimplantation \u221274.6\u2009\u00b1\u200925.8 vs. \u221229.1\u2009\u00b1\u200917.8%, 3\u2010months follow\u2010up \u221265.8\u2009\u00b1\u200931.2 vs. \u221233.9\u2009\u00b1\u200917.5%, 12\u2010months follow\u2010up \u221250.8\u2009\u00b1\u200927.9 vs. \u221223.9\u2009\u00b1\u200917.0%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Qualitative mitral valve assessment showed improved FMR class postimplantation, at 3\u2010and 12\u2010months follow\u2010up in both treatment groups. Edge\u2010to\u2010edge repair revealed better results with lower average FMR classification compared to indirect coronary sinus\u2010based annuloplasty. After 12\u2010months left atrial (LA) volume was significantly reduced in the Carillon group, while in the MitraClip group no LA remodeling was found (reduction in LA volume MitraClip vs. Carillon at 12 months: +9.6\u2009\u00b1\u200925.1% vs. \u221212.3\u2009\u00b1\u200912.7%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both indirect mitral valve annuloplasty and edge\u2010to\u2010edge repair are feasible and safe in patients with aFMR, while the reduction in FMR was pronounced in the edge\u2010to\u2010edge repair group.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30157","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T12:50:08Z","timestamp":1647867008000},"page":"1839-1847","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Mitral valve edge\u2010to\u2010edge repair versus indirect mitral valve annuloplasty in atrial functional mitral regurgitation"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8789-9092","authenticated-orcid":false,"given":"Dennis","family":"Rottl\u00e4nder","sequence":"first","affiliation":[{"name":"Department of Cardiology Rheinland Klinikum Neuss Neuss Germany"},{"name":"Department of Cardiology Krankenhaus Porz am Rhein Cologne Germany"},{"name":"Faculty of Health, School of Medicine University Witten\/Herdecke Witten Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milad","family":"Golabkesh","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rheinland Klinikum Neuss Neuss Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubertus","family":"Degen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rheinland Klinikum Neuss Neuss Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alev","family":"\u00d6g\u00fctc\u00fc","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rheinland Klinikum Neuss Neuss Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Saal","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rheinland Klinikum Neuss Neuss Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Haude","sequence":"additional","affiliation":[{"name":"Department of Cardiology Rheinland Klinikum Neuss Neuss Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,21]]},"reference":[{"issue":"58","key":"e_1_2_9_2_1","first-page":"1474","article-title":"Evidence of atrial functional mitral regurgitation due to atrial fibrillation: reversal with arrhythmia control","volume":"201","author":"Gertz ZM","journal-title":"J Am 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