{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T17:04:23Z","timestamp":1788627863363,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T00:00:00Z","timestamp":1649894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To date, extensive experience in transcatheter closure of fenestrated atrial septal aneurysm (ASA) in the pediatric population is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To report on procedural feasibility, efficacy, and long\u2010term outcome, we enrolled all children submitted to an attempt of transcatheter closure of fenestrated ASA at two, large volume, pediatric cardiology units (Naples and Massa, Italy) between April 2000 to May 2020.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This retrospective study included 139 patients (median age 9 years [range 2\u201318]\u00a0and weight 36\u2009kg [range 10\u2013102]); 19 (13.7%) children were \u226420\u2009kg (range 10\u201320) and 14 (10.1%) were \u22645 years old. Single perforation was observed in 28 patients (20.1%), while 111 patients (79.9%) had multifenestrated ASA. The median size of the main defect was 15\u2009mm (range 6\u201334) and 25 patients (18%) had a defect \u226520\u2009mm. The procedural success rate was 99% (95% confidence interval [CI]: 94.9\u201399.8) using a single device in 75 (69%), two devices in 31 (28%), and three devices in 3 (3%) cases. Early minor adverse events (AEs) occurred in four patients (2.8%). Late minor AEs\u00a0were recorded in one patient (0.7%) over a median follow\u2010up of 5 years ([range 0\u201318 years; total 890.2 person\u2010years, and with 30 patients (22%) followed \u226510 years). Neither mortality nor major AEs were recorded. Freedom from AEs was 99.1% at 10\u201315 years (95% CI: 93.5\u201399.8%), without any difference according to atrial septum anatomy or patient age and weight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Transcatheter closure of fenestrated ASA is technically feasible and effective in children with excellent long\u2010term outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30191","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T09:11:42Z","timestamp":1649927502000},"page":"2043-2053","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Transcatheter closure of fenestrated atrial septal aneurysm in children: Feasibility and long\u2010term results"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6171-5630","authenticated-orcid":false,"given":"Heba Talat","family":"Mahmoud","sequence":"first","affiliation":[{"name":"Pediatric Cardiology University of Campania \u201cLuigi Vanvitelli\u201d \u201cOspedali dei Colli\u201d Naples Italy"},{"name":"Cardiology Department Minia University Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianpiero","family":"Gaio","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology University of Campania \u201cLuigi Vanvitelli\u201d \u201cOspedali dei Colli\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0583-5221","authenticated-orcid":false,"given":"Mario","family":"Giordano","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology University of Campania \u201cLuigi Vanvitelli\u201d \u201cOspedali dei Colli\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Pizzuto","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology and GUCH Unit, Heart Hospital \u201cG. Pasquinucci\u201d National Research Council\u2010Tuscany Region Foundation \u201cG. Monasterio\u201d Massa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madgalena","family":"Cuman","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology and GUCH Unit, Heart Hospital \u201cG. Pasquinucci\u201d National Research Council\u2010Tuscany Region Foundation \u201cG. Monasterio\u201d Massa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Abdel Kader","family":"Abdel Wahab","sequence":"additional","affiliation":[{"name":"Cardiology Department Minia University Minia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Palladino","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology University of Campania \u201cLuigi Vanvitelli\u201d \u201cOspedali dei Colli\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Giovanna","family":"Russo","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology University of Campania \u201cLuigi Vanvitelli\u201d \u201cOspedali dei Colli\u201d Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6071-6973","authenticated-orcid":false,"given":"Giuseppe","family":"Santoro","sequence":"additional","affiliation":[{"name":"Pediatric Cardiology University of Campania \u201cLuigi Vanvitelli\u201d \u201cOspedali dei Colli\u201d Naples Italy"},{"name":"Pediatric Cardiology and GUCH Unit, Heart Hospital \u201cG. 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