{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:10:14Z","timestamp":1771233014501,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:00:00Z","timestamp":1651190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Despite limited to short and midterm outcomes, valve\u2010in\u2010valve (ViV) transcatheter aortic valve implantation (TAVI) has emerged as a valid alternative to re\u2010surgical aortic valve replacement (re\u2010SAVR) for high\u2010 and intermediate\u2010risk patients with degenerated surgical bioprosthesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All studies comparing multivariate adjustment between ViV TAVI and re\u2010SAVR were screened. The primary end\u2010points were all\u2010cause and cardiovascular (CV) mortality at 30 days and at Midterm follow\u2010up. Short\u2010term complications were the secondary endpoints.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We obtained data from 11 studies, encompassing 8570 patients, 4224 undergoing ViV TAVI, and 4346 re\u2010SAVR. Four studies included intermediate\u2010risk patients and seven high\u2010risk patients. 30\u2010day all\u2010cause and CV mortality were significantly lower in ViV (odds ratio [OR] 0.43, 95% confidence intervals [CIs] 0.29\u20130.64 and OR 0.44, 0.26\u20130.73 respectively), while after a mean follow\u2010up of 717 (180\u20131825) days, there was no difference between the two groups (OR 1.04, 0.87\u20131.25 and OR 1.05, 0.78\u20131.43, respectively). The risk of stroke (OR 1.03, 0.59\u20131.82), MI (OR 0.70, 0.34\u20131.44), major vascular complications (OR 0.92, 0.50\u20131.67), and permanent pacemaker implantation (OR 0.67, 0.36\u20131.25) at 30 days did not differ, while major bleedings and new\u2010onset atrial fibrillation were significantly lower in ViV patients (OR 0.41, 0.25\u20130.67 and OR 0.23, 0.12\u20130.42, respectively, all 95% CIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In high\u2010 and intermediate\u2010risk patients with degenerated surgical bioprostheses, ViV TAVI is associated with reduced short\u2010term mortality, compared with re\u2010SAVR. Nevertheless, no differences were found in all\u2010cause and CV mortality at midterm follow\u2010up. 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