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The process may be potentiated by reversal of the usual trans\u2010atrial pressure gradient, or from alteration of intracardiac geometry such that venous flow is preferentially directed toward the PFO. We describe a series of four patients who presented with hypoxemia, detailing the diagnostic evaluation which led to the ascertainment of intracardiac RTLS across PFO as the culprit pathology. All underwent successful percutaneous closure with rapid resolution of hypoxemia. Particular attention is given to the underlying anatomic and physiologic derangements facilitating the intracardiac RTLS.<\/jats:p>","DOI":"10.1002\/ccd.30317","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T10:40:38Z","timestamp":1656326438000},"page":"471-475","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Percutaneous closure of patent foramen ovale for treatment of hypoxemia: A case series and physiology review"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7965-7499","authenticated-orcid":false,"given":"Jared","family":"Robl","sequence":"first","affiliation":[{"name":"Department of Internal Medicine,\u00a0Division of Cardiovascular Medicine University of Iowa Iowa City Iowa 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