{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:11:43Z","timestamp":1785222703328,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T00:00:00Z","timestamp":1657929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess feasibility and safety of second\u2010generation left atrial appendage closure (LAAC) Ultraseal device in patients with nonvalvular atrial fibrillation (NVAF).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>LAAC with first\u2010generation Ultraseal device (Cardia, Eagan, Minnesota) has been shown to be a feasible therapeutic option in patients with NVAF. However, there is a paucity of data regarding the novel second\u2010generation Ultraseal device.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients with NVAF undergoing second\u2010generation Ultraseal device implantation between February 2018 and September 2020 were included in a multicenter international registry. Periprocedural and post\u2010discharge events were collected through 6\u2010month follow\u2010up. Co\u2010primary efficacy endpoints were device success and technical success while primary safety endpoint was in\u2010hospital major adverse event (MAE) occurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 52 patients were included: mean age 75\u2009\u00b1\u20098, 30.8% women, mean HAS\u2010BLED 3\u2009\u00b1\u20091. The device was successfully implanted in all patients. Technical success was achieved in 50 patients (96.1%). In\u2010hospital MAEs occurred in three patients (5.8%). The incidence of 6\u2010month all\u2010cause death and major bleeding was 11.6% and 2.1%, respectively. No strokes, transient ischemic attacks, systemic embolisms, or device embolization were reported after discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Second\u2010generation Ultraseal device implantation was associated with high success rates and a low incidence of peri\u2010procedural complications. Larger studies with longer follow\u2010up are warranted to further evaluate the safety and the efficacy of this device, especially at long\u2010term follow\u2010up.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30336","type":"journal-article","created":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T06:11:47Z","timestamp":1658038307000},"page":"620-627","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Left atrial appendage closure with the II generation Ultraseal device:\u00a0<b>An international registry. The LIGATE study<\/b>"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5195-8815","authenticated-orcid":false,"given":"Carlo A.","family":"Pivato","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Pieve Emanuele\u2010Milan Italy"},{"name":"Cardio Center IRCCS Humanitas Research Hospital  Rozzano\u2010Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3883-1622","authenticated-orcid":false,"given":"Gaetano","family":"Liccardo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Humanitas University  Pieve Emanuele\u2010Milan Italy"},{"name":"Cardio Center IRCCS Humanitas Research Hospital  Rozzano\u2010Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4991-6549","authenticated-orcid":false,"given":"Jorge","family":"Sanz\u2010Sanchez","sequence":"additional","affiliation":[{"name":"Cardiology Department Hospital Universitari i Polit\u00e8cnic La Fe  Valencia Spain"},{"name":"Centro de Investigaci\u00f3n Biomedica en Red (CIBERCV) Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Pelloni","sequence":"additional","affiliation":[{"name":"Ospedale Regionale U. 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