{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T12:44:00Z","timestamp":1750250640944,"version":"3.37.3"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:00:00Z","timestamp":1659052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Morbidity with surgical systemic\u2010to\u2010pulmonary artery shunting (SPS) in infants \u22642.5\u2009kg has remained high. Patent ductus arteriosus (PDA) stenting may be a valid alternative. The objective of this study is\u00a0to evaluate outcomes following PDA stenting in patients \u22642.5\u2009kg from four large tertiary centers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of all neonates \u22642.5\u2009kg with duct\u2010dependent pulmonary circulation who underwent PDA stenting. Procedural details, pulmonary arterial growth, reinterventions, surgery type, and outcomes were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PDA stents were implanted in 37 of 38 patients attempted (18 female) at a median procedural weight of 2.2\u2009kg (interquartile range\u00a0[IQR], 2\u20132.4\u2009kg). Seven patients (18%) had a genetic abnormality and 16 (42%) had associated comorbidities. The median intensive care unit stay was 4 days (IQR, 2\u20136.75 days), and the median hospital stay was 20 days (IQR, 16\u201357.25). One patient required a rescue shunt procedure, with three others requiring early SPS (&lt;30 days postprocedure). Twenty patients (54%) required reintervention with either balloon angioplasty, restenting, or both. At 6\u2010month follow\u2010up, right pulmonary artery growth (median <jats:italic>z<\/jats:italic>\u2010score \u22121.16 to 0.01, <jats:italic>p<\/jats:italic>\u2009=\u20090.05) was greater than the left pulmonary artery (median <jats:italic>z<\/jats:italic>\u2010score \u22120.9 to \u22120.64, <jats:italic>p<\/jats:italic>\u2009=\u20090.35). Serious adverse effects (SAEs) were seen in 18% (<jats:italic>N<\/jats:italic>\u2009=\u20097) of our cohort. One patient developed an SAE during planned reintervention There were no intraprocedural deaths, with one early procedure\u2010related mortality, and three interstage mortalities not directly related to PDA stenting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PDA stenting in infants \u22642.5\u2009kg is feasible and effective, promoting pulmonary artery growth. Reintervention rates are relatively high, though many are planned to allow for optimal growth before a definitive operation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30351","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T11:39:49Z","timestamp":1659094789000},"page":"596-605","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Short\u2010 and medium\u2010term outcomes for patent ductus arteriosus stenting in neonates \u22642.5\u2009kg with duct\u2010dependent pulmonary circulation"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0909-6291","authenticated-orcid":false,"given":"Mohamed Al","family":"Nasef","sequence":"first","affiliation":[{"name":"Children Health Ireland at Crumlin Dublin Ireland"},{"name":"Prince Sultan Cardiac Center Riyadh Kingdom of Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doaa A.","family":"Shahbah","sequence":"additional","affiliation":[{"name":"The Lillie Frank Abercrombie Section of Cardiology, Department of Pediatrics Texas Children's Hospital,\u00a0Baylor College of Medicine Houston Texas USA"},{"name":"Department of Pediatric Cardiology Department Faculty of Medicine Zagazig University Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8795-9526","authenticated-orcid":false,"given":"Sarosh P.","family":"Batlivala","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Department Cincinnati Children's Hospital University of Cincinnati College of Medicine Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reem","family":"Darwich","sequence":"additional","affiliation":[{"name":"Prince Sultan Cardiac Center Riyadh Kingdom of Saudi 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