{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T19:59:50Z","timestamp":1778529590840,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T00:00:00Z","timestamp":1663459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transcatheter aortic valve\u2010in\u2010valve implantation (ViV\u2010TAVI) has emerged in recent years as a safe alternative to redo surgery in high\u2010risk patients. Although early results are encouraging, data beyond short\u2010term outcomes are lacking. Herein, we aimed to assess the 2\u2010year outcomes after ViV\u2010TAVI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients undergoing ViV\u2010TAVI for degenerated surgical valves between 2013 and 2019 at the Cleveland Clinic were reviewed. The coprimary endpoints were all\u2010cause mortality and congestive heart failure (CHF) hospitalizations. We used time\u2010to\u2010event analyses to assess the primary outcomes. Further, we measured the changes in transvalvular gradients and the incidence of structural valve deterioration (SVD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and eighty\u2010eight patients were studied (mean age\u2009=\u200976 years; 65% males). At 2 years of follow\u2010up, all\u2010cause mortality and CHF hospitalizations occurred in 15 (8%) and 28 (14.9%) patients, respectively. On multivariable analysis, the postprocedural length of stay was a significant predictor for both all\u2010cause mortality (hazard ratio [HR]\u2009=\u20091.1; 95% confidence interval [CI]: 1.01, 1.19) and CHF hospitalization (HR\u2009=\u20091.16; 95% CI: 1.07, 1.27). However, the internal diameter of the surgical valve was not associated with significant differences in both primary endpoints. For hemodynamic outcomes, nine patients (4.8%) developed SVD. The mean and peak transvalvular pressure gradients remained stable over the follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>ViV\u2010TAVI for degenerated surgical valves was associated with favorable 2\u2010year clinical and hemodynamic outcomes. Further studies are needed to better understand the role of ViV\u2010TAVI as a treatment option in the life management of aortic valve disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30388","type":"journal-article","created":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T09:30:30Z","timestamp":1663493430000},"page":"860-867","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Two\u2010year outcomes after transcatheter aortic valve\u2010in\u2010valve implantation in degenerated surgical valves"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1399-6487","authenticated-orcid":false,"given":"Abdelrahman I.","family":"Abushouk","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Heart, Vascular &amp; Thoracic Institute Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8025-9212","authenticated-orcid":false,"given":"Omar","family":"Abdelfattah","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Heart, Vascular &amp; Thoracic Institute Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0218-3317","authenticated-orcid":false,"given":"Mohamed M.","family":"Gad","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Heart, Vascular &amp; Thoracic Institute Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anas","family":"Saad","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Heart, Vascular &amp; Thoracic Institute Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Essa","family":"Hariri","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Heart, Vascular &amp; Thoracic Institute Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2172-6447","authenticated-orcid":false,"given":"Toshiaki","family":"Isogai","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Heart, Vascular &amp; Thoracic Institute Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shashank","family":"Shekhar","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Heart, Vascular &amp; Thoracic Institute Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant W.","family":"Reed","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Heart, Vascular &amp; Thoracic Institute Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rishi","family":"Puri","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Heart, Vascular &amp; Thoracic Institute Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Heart, Vascular &amp; Thoracic Institute Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick R.","family":"Vargo","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Heart, Vascular &amp; Thoracic Institute Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron J.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Heart, Vascular &amp; Thoracic Institute Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Burns","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Heart, Vascular &amp; Thoracic Institute Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Unai","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Heart, Vascular &amp; Thoracic Institute Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoran","family":"Popovic","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Heart, Vascular &amp; Thoracic Institute Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge C.","family":"Harb","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Heart, Vascular &amp; Thoracic Institute Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6048-7955","authenticated-orcid":false,"given":"Amar","family":"Krishnaswamy","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Heart, Vascular &amp; Thoracic Institute Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars G.","family":"Svensson","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Heart, Vascular &amp; Thoracic Institute Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas R.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery, Heart, Vascular &amp; Thoracic Institute Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0026-3391","authenticated-orcid":false,"given":"Samir R.","family":"Kapadia","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Heart, Vascular &amp; Thoracic Institute Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.09.030"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.05.66"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.04.074"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-18-00752"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.035"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.29543"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-19-00928"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.104505"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.7246"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2011.03.016"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa799"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx303"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.030729"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2019.03.084"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.02.035"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.118.007038"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-18-01197"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2018.04.042"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.30388","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.30388","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.30388","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T08:32:55Z","timestamp":1692693175000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.30388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,18]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1002\/ccd.30388"],"URL":"https:\/\/doi.org\/10.1002\/ccd.30388","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,18]]},"assertion":[{"value":"2021-08-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}