{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:11:52Z","timestamp":1771233112168,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Left main stem percutaneous coronary intervention (LMS\u2010PCI) is a complex high\u2010risk procedure which can be performed as an alternative to coronary artery bypass graft (CABG) procedure in surgical turn\u2010down patients or where there is equipoise in percutaneous versus surgical strategies. Current guidelines suggest that PCI is an appropriate alternative to CABG in patients with unprotected LMS disease and low SYNTAX score. However, \u201creal world\u201d\u00a0data on outcomes of LMS\u2010PCI remain limited. This study aims to quantify and determine predictors of mortality following LMS\u2010PCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using local coronary angioplasty registries from two UK centers, all LMS\u2010PCI cases were identified from 2016 to 2020. Descriptive statistics and multivariate logistic regressions were used to examine the association between baseline and procedural characteristics with 30\u2010day and 12\u2010month mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 484 cases of LMS\u2010PCI between 2016 and 2020. There was a year\u2010on\u2010year increase in the number of LMS\u2010PCI, the highest being in 2020. Covariates associated with higher 30\u2010day mortality were age (OR 1.07, 95% CI: 1.02\u22121.12) and shock preprocedure (OR 23.88, 95% CI: 7.90\u221272.20). Covariates associated with higher 12\u2010month mortality were age (OR 1.04, 95% CI: 1.01\u22121.08), acute coronary syndrome (ACS)\u00a0(OR 2.50, 95% CI: 1.08\u22125.80), renal disease (OR 5.24, 95% CI: 1.47\u221218.68), and shock preprocedure (OR 7.93, 95% CI: 3.30\u221219.05). Overall, 30\u2010day and 12\u2010month mortality in this contemporary data set were 9.5% and 16.7%, respectively, with significantly lower rates in elective cases (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Older age and cardiogenic shock preprocedure were associated with increased 30\u2010day mortality after LMS\u2010PCI.\u00a0Twelve\u2010month mortality was associated with older age, ACS presentation, preexisting\u00a0renal disease, and cardiogenic shock preprocedure.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30400","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T04:39:09Z","timestamp":1663216749000},"page":"585-592","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Predictors of 30\u2010day and 12\u2010month mortality in left main stem percutaneous coronary intervention 2016\u22122020: A study from two UK centers"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3478-0407","authenticated-orcid":false,"given":"Elliott J.","family":"Carande","sequence":"first","affiliation":[{"name":"Department of Cardiology Morriston Cardiac Centre Swansea UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8992-9120","authenticated-orcid":false,"given":"Majd B.","family":"Protty","sequence":"additional","affiliation":[{"name":"Systems Immunity University Research Institute Cardiff University Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Verhemel","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Grange University Hospital Cwmbran UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7769-8089","authenticated-orcid":false,"given":"Mohammed H.","family":"Hussein","sequence":"additional","affiliation":[{"name":"Department of Cardiology Morriston Cardiac Centre Swansea UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay S.","family":"Raman","sequence":"additional","affiliation":[{"name":"Department of Cardiology Morriston Cardiac Centre Swansea UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zia","family":"UlHaq","sequence":"additional","affiliation":[{"name":"Department of Cardiology Morriston Cardiac Centre Swansea UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shantu","family":"Bundhoo","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Grange University Hospital Cwmbran UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Cullen","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Grange University Hospital Cwmbran UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Ionescu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Morriston Cardiac Centre Swansea UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anirban","family":"Choudhury","sequence":"additional","affiliation":[{"name":"Department of Cardiology Morriston Cardiac Centre Swansea UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussain I.","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Grange University Hospital Cwmbran UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Hailan","sequence":"additional","affiliation":[{"name":"Department of Cardiology Morriston Cardiac Centre Swansea UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.20709"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.07.007"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1610227"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.68.5.939"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198808113190603"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi138"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804626"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32052-9"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy394"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2011-300299"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carrev.2019.08.016"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2019.10.007"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-0770(03)00202-7"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/joic.12466"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.03.005"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000525"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4587414"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.004598"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.12.038"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.03.054"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezx334"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.30400","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.30400","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.30400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T09:28:13Z","timestamp":1692696493000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.30400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,14]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1002\/ccd.30400"],"URL":"https:\/\/doi.org\/10.1002\/ccd.30400","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,14]]},"assertion":[{"value":"2022-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}