{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:53:22Z","timestamp":1787939602612,"version":"build-2784847793"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T00:00:00Z","timestamp":1664668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Transcatheter aortic valve implantation (TAVI) has increasingly been utilized in patients with bicuspid aortic valve (BAV) related aortic stenosis (AS) with insufficient large\u2010scale data on its safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Nationwide Inpatient Sample and Nationwide Readmission Database (2011\u20132018) were queried to identify patients undergoing TAVI for BAV versus trileaflet aortic valve (TAV) associated AS. The in\u2010hospital, 30\u2010 and 180\u2010day odds of outcomes were assessed using a propensity\u2010matched analysis (PSM) to calculate adjusted odds ratios (aOR) with its 95% confidence interval (CI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 216,723 TAVI (TAV: 214,050 and BAV: 2,673) crude and 5,347 matched population (TAV: 2,674 and BAV: 2,673) was included in the final analysis. At index admission, the adjusted odds of in\u2010hospital mortality (aOR: 1.57, 95% CI: 0.67\u20133.66), stroke (aOR: 0.77, 95% CI: 0.38\u20131.57), cardiac tamponade (aOR: 0.75, 95% CI: 0.17\u20133.36), vascular complications (aOR: 0.33, 95% CI: 0.09\u20131.22), cardiogenic shock (aOR: 1.77, 95% CI: 0.93\u20133.38), paravalvular leak (aOR: 0.55, 95% CI: 0.26\u20131.14), need for mechanical circulatory support device, and permanent pacemaker implantation (PPM) (aOR: 1.02, 95% CI: 0.69\u20131.52) were not significantly different between TAVI for BAV versus TAV. At 30\u2010 and 180\u2010day follow\u2010up duration, the risk of stroke and major postprocedural complications remained similar, except that TAVI in BAV had a higher incidence of PPM implantation compared with TAV. The yearly trend showed an increase in the utilization of TAVI for both TAV and BAV and a steady decline in the overall annual rate of in\u2010hospital complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TAVI utilization in patients with BAV has increased over the recent years. The relative odds of in\u2010hospital mortality, and all other major complications, were similar between patients undergoing TAVI for BAV\u2010 and TAV\u2010related AS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.30407","type":"journal-article","created":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T18:35:05Z","timestamp":1664735705000},"page":"1119-1131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Trends, predictors, and outcomes of transcatheter aortic valve implantation in patients with bicuspid aortic valve related disease: Insights from the Nationwide Inpatient Sample and Nationwide Readmission Database"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4850-0309","authenticated-orcid":false,"given":"Waqas","family":"Ullah","sequence":"first","affiliation":[{"name":"Division of Cardiology Thomas Jefferson University Hospitals Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2754-9397","authenticated-orcid":false,"given":"Salman","family":"Zahid","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Rochester Regional Health Rochester New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza","family":"Muhammadzai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Abington Jefferson Health Abington Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8241-4324","authenticated-orcid":false,"given":"Fouad","family":"Khalil","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of South Dakota Vermillion South Dakota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnav","family":"Kumar","sequence":"additional","affiliation":[{"name":"Division of Cardiology Brigham and Women's Hospital Heart &amp; Vascular Center Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9829-3520","authenticated-orcid":false,"given":"Abdul Mannan Khan","family":"Minhas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Forest General Hospital Hattiesburg Mississippi USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8473-8069","authenticated-orcid":false,"given":"Muhammad Zia","family":"Khan","sequence":"additional","affiliation":[{"name":"Division of Cardiology West Virginia University Hospital Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salim S.","family":"Virani","sequence":"additional","affiliation":[{"name":"Division of Cardiology Baylor College of Medicine Houston Texas USA"},{"name":"Division of Cardiology Michael E. DeBakey VA Medical Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9711-7616","authenticated-orcid":false,"given":"David L.","family":"Fischman","sequence":"additional","affiliation":[{"name":"Division of Cardiology Thomas Jefferson University Hospitals Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1642-7557","authenticated-orcid":false,"given":"Pinak","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Cardiology Brigham and Women's Hospital Heart &amp; Vascular Center Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak L.","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Division of Cardiology Brigham and Women's Hospital Heart &amp; Vascular Center Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.27205"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103510"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1514616"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814052"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2020.03.022"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.7108"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2016.01.002"},{"key":"e_1_2_9_9_1","first-page":"14","article-title":"Transcatheter aortic valve implantation: indications","volume":"14","author":"Pi\u00e9rard L","year":"2016","journal-title":"Euro Soc Cardiol"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.118.007107"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.09.039"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.03.017"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/clc.22992"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.121.020906"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv191"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2020.12.087"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.05.063"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2014.12.163"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.13346"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000155623.48408.C5"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.17653"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.30407","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ccd.30407","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.30407","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T16:48:23Z","timestamp":1692463703000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.30407"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,2]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1002\/ccd.30407"],"URL":"https:\/\/doi.org\/10.1002\/ccd.30407","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,2]]},"assertion":[{"value":"2022-09-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}